N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate Purity High
Pasokan Komérsial Imatinib Mesylate sareng Panganteur Patali:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Metil-5-nitrofenil)-4-(piridin-3-yl)pirimidin-2-amin CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-piridil)-2-pirimidina CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)métil] asam bénzoat dihidroklorida CAS: 106261-49-8
| Ngaran Kimia | N-(5-Amino-2-methylphenyl)-4-(3-piridil)-2-pirimidinea |
| sinonim | Imatinib Mesylate panengah;2-(5-Amino-2-methylanilino)-4-(3-piridil)pirimidin |
| Nomer CAS | 152460-10-1 |
| Nomer CAT | RF-PI230 |
| Status saham | Dina Stok, Skala Produksi Nepi ka Ton |
| Formula Molekul | C16H15N5 |
| Beurat Molekul | 277.32 |
| Titik Lebur | 133,0-135,0 ℃ |
| merek | Kimia Ruifu |
| Barang | spésifikasi |
| Penampilan | Lampu Oranyeu kana Bubuk Konéng ka Kristal |
| Kamurnian / Métode Analisis | ≥98,0% |
| Leungitna dina Drying | ≤0,50% |
| Sésa dina ignition | ≤0,50% |
| Total Kotoran | ≤2,0% |
| Maksimum Single Impurity | ≤1,0% |
| Logam beurat | ≤20ppm |
| Standar tés | Standar Perusahaan |
| Pamakéan | Panganteur Imatinib Mesylate (CAS: 220127-57-1) |
Bungkusan: Botol, kantong Aluminium foil, kardus drum, 25kg / Drum, atawa nurutkeun sarat customer urang.
Kaayaan Panyimpenan:Simpen dina wadah anu disegel dina tempat anu tiis sareng garing;Ngajaga tina cahaya, Uap jeung infestation hama.
Shanghai Ruifu Chemical Co., Ltd. nyaéta produsén ngarah sareng supplier N-(5-Amino-2-methylphenyl) -4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) kalayan kualitas luhur .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) mangrupa perantara ilaharna dina sintésis Imatinib Mesylate (CAS: 220127-57-1). ) API.
Imatinib mesylate mangrupakeun molekul leutik nu ngahambat c-Abl protéin-tirosin kinase, hiji kinase husus penting pikeun proliferasi leukemia myelogenous kronis (CML).Kajadian translokasi antara kromosom 9 jeung 22 ngahasilkeun kromosom Philadelphia, nu saterusna ngahasilkeun protéin fusi Bcr-Abl kalawan aktivitas kinase nyimpang nu promotes proliferasi sél gancang.Imatinib mesylate ngiket kinase krusial ieu, halting tumuwuhna patali CML.Imatinib mesylate parantos ditingalikeun pikeun ngahambat PDGFR sareng kinase tirosin anu aya hubunganana sareng c-Kit.Formulasi anu ngandung Imatinib mesylate parantos dianggo dina pengobatan sagala rupa kangker.
Imatinib mesylate mangrupikeun inhibitor tirosin kinase.Kacida spésifik pikeun BCR-ABL, énzim pakait sareng leukemia myelogenous kronis (CML) sareng sababaraha bentuk leukemia limfoblastik akut (ALL).Ieu mangrupakeun v-Abl tirosin kinase inhibitor potent tur selektif (IC50 = 38 nM).Ogé ngahambat PDGFR sareng c-kit.Némbongkeun selektivitas pikeun v-Abl leuwih panel tirosin sejen tur serin / threonine protéin kinase.Selektif ngahambat pertumbuhan PDGF-dirangsang tina v-abl-transformasi sél PB-3 jeung v-sis-transformasi sél BALB / c 3T3 in vitro.Némbongkeun épék antitumor dina beurit anu ngandung sél AMuLV atanapi BABL / c 3T3 v-sis.Ngahambat réplikasi SARS-CoV sareng MERS-CoV in vitro (Nilai EC50 masing-masing 9.823 sareng 17.689 μM).
![4- [(4-Methylpiperazin-1-yl)métil] asam bénzoat dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate Purity High](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)