Asam Zoledronic CAS 118072-93-8 Purity ≥99.7% Pabrik API Kualitas Luhur
Pasokan sareng Purity High sareng Kualitas Stabil
Ngaran Kimia: Zoledronic Acid
CAS: 118072-93-8
Potent Farnesyl Diphosphate (FPP) Synthase Inhibitor
API Quality High, Produksi komérsial
| Ngaran Kimia | Asam Zoledronic |
| sinonim | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-étildéna]asam bifosfonik |
| Nomer CAS | 118072-93-8 |
| Nomer CAT | RF-API90 |
| Status saham | Dina Stok, Skala Produksi Nepi ka Ratusan Kilogram |
| Formula Molekul | C5H10N2O7P2 |
| Beurat Molekul | 272.09 |
| Titik lebur | 193,0 ~ 204,0 ℃ |
| merek | Kimia Ruifu |
| Barang | spésifikasi |
| Penampilan | Bodas ka Pareum-Bodas Bubuk Kristal |
| Idéntifikasi | Spéktrum IR tina sampel saluyu sareng standar rujukan |
| pH | 2.0~4.0 |
| Kalarutan | Saeutik leyur dina 0.1N Sodium Hydroxide Solution, Rada Leyur dina Cai jeung 0.1N Hydrochloric Acid, Praktis Teu Leyur dina Étanol |
| Zat Patali | |
| Sakur Najis Pribadi | ≤0,10% |
| Total Kotoran | ≤0,30% |
| Leungitna dina Drying | 5,0%~7,0% |
| Klorida | ≤0,02% |
| fosfit | ≤0,50% |
| fosfat | ≤0,50% |
| Logam beurat | ≤10ppm |
| Kasucian | ≥99,7% |
| Standar tés | Standar Perusahaan |
| Pamakéan | API, FPP Synthase Inhibitor, Hypercalcemia of Malignancy (HCM) |
Bungkusan: Botol, kantong Aluminium foil, kardus drum, 25kg / Drum, atawa nurutkeun sarat customer urang.
Kaayaan Panyimpenan:Simpen dina wadah anu disegel dina tempat anu tiis sareng garing;Ngajaga tina cahaya, Uap jeung infestation hama.
Asam Zoledronic (CAS 118072-93-8) mangrupikeun inhibitor sintase bisphophonate farnesyl diphosphate (FPP) anu kuat (IC50=20 nM).Ngahambat resorpsi tulang anu dimédiasi osteoklas.Ogé ngahambat sinyal Ras sareng kamekaran tumor, sareng nyababkeun apoptosis dina sél kanker pankréas.Ngabalikeun transisi épitél-mesenchymal sareng ngahambat pembaharuan sél kanker payudara ku cara nganonaktipkeun NF-κB.Asam Zoledronic disatujuan ku FDA AS dina 2001 pikeun pengobatan hypercalcemia of malignancy, komplikasi métabolik anu tiasa ngancam kahirupan.Hypercalcemia of malignancy bisa lumangsung dina nepi ka 50% pasien didiagnosis kalawan kanker payudara canggih, multiple myeloma, sarta kanker paru sél nonsmall.Kaayaan ieu timbul nalika gugus kimiawi anu dihasilkeun ku tumor ngabalukarkeun overstimulasi osteoklas.Nalika aya paningkatan degradasi tulang, aya sékrési kalsium sakaligus kana plasma.Nalika konséntrasi sérum kalsium gancang ningkat, ginjal henteu tiasa nahan kaleuleuwihan, sareng nyababkeun hypercalcemia.Asam Zoledronic sacara efektif ngirangan konsentrasi kalsium plasma ku cara ngahambat resorpsi tulang (inhibisi kagiatan osteoclastic sareng induksi apoptosis osteoklas).Salaku tambahan, asam zoledronic parantos disatujuan ku FDA AS pikeun pengobatan sababaraha myeloma sareng metastase tulang anu aya hubunganana sareng kanker dumasar-tumor padet (contona, sujud sareng paru-paru).
