4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9 Purity >98.5% (HPLC) Lenvatinib Mesylate Intermediate Factory
Ugavi wa Kemikali wa Ruifu Lenvatinib Mesylate Inapatana na Usafi wa Juu
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinil Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Jina la Kemikali | 4-Chloro-7-Methoxyquinoline-6-Carboxamide |
Visawe | 4-Chloro-7-Methoxy-6-Quinolinecarboxes;Uchafu wa Lenvatinib 12;Uchafu wa Lenvatinib B;Uchafu wa Lenvatinib LFS-B |
Nambari ya CAS | 417721-36-9 |
Nambari ya CAT | RF-PI1971 |
Hali ya Hisa | Katika Hisa, Uwezo wa Uzalishaji 50MT/Mwaka |
Mfumo wa Masi | C11H9ClN2O2 |
Uzito wa Masi | 236.65 |
Kiwango cha kuyeyuka | >205℃ (Desemba) |
Msongamano | 1.380±0.060 g/cm3 |
Chapa | Ruifu Chemical |
Kipengee | Vipimo |
Mwonekano | Nyeupe-nyeupe hadi Poda Isiyokolea ya Njano |
Njia ya Usafi / Uchambuzi | >98.5% (HPLC) |
Kupoteza kwa Kukausha | <0.50% |
Mabaki kwenye Kuwasha | <0.50% |
Jumla ya Uchafu | <1.50% |
Protoni NMR Spectrum | Inalingana na Muundo |
Kiwango cha Mtihani | Kiwango cha Biashara |
Matumizi | Kati ya Lenvatinib Mesylate (CAS: 857890-39-2) |
Kifurushi: Chupa, begi ya karatasi ya Alumini, Ngoma ya 25kg/Cardboard, au kulingana na mahitaji ya mteja
Hali ya Uhifadhi:Hifadhi kwenye vyombo vilivyofungwa mahali pa baridi na kavu;Kinga kutoka kwa mwanga na unyevu
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4-Chloro-7-Methoxyquinoline-6-Carboxamide (CAS: 417721-36-9) hutumiwa zaidi kama kiungo cha kati cha Lenvatinib Mesylate (CAS: 857890-39-2).Imetengenezwa na Eisai Inc., lenvatinib mesylate ni kizuizi cha kipokezi cha ukuaji wa mishipa ya damu (VEGF) ambayo ina shughuli dhidi ya aina ndogo za VEGF 1, 2, na 3 na iliidhinishwa na FDA mnamo 2015 kwa matibabu ya saratani tofauti ya tezi ambayo iko ndani ya nchi. ya mara kwa mara, metastatic, au inayoendelea na haikujibu matibabu ya iodini ya mionzi.Mnamo Mei 2016, FDA iliidhinisha dawa hiyo kama tiba mchanganyiko na everolimus kwa matibabu ya saratani ya seli ya figo iliyoendelea.Kwa sababu VEGF (na vipokezi vya ukuaji wa fibroblast, vinavyojulikana kama FGFRs) vinafikiriwa kuwa na jukumu katika njia za kuashiria moyo na mishipa, uzuiaji wa VEGF2R na FGFR unafikiriwa kuwa mbinu nyuma ya athari ya msingi ya lenvatinib mesylate, ambayo ni shinikizo la damu.
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