![7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Picha Iliyoangaziwa ya Tolvaptan](https://www.ruifuchemical.com/uploads/7-Chloro-1234-tetrahydrobenzobazepin-5-one-CAS-160129-45-3.jpg)
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate
Ugavi wa Watengenezaji, Ubora wa Juu, Uzalishaji wa Biashara
Tolvaptan na Wasaidizi Wanaohusiana:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
| Jina la Kemikali | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one |
| Visawe | 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-moja;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-moja |
| Nambari ya CAS | 160129-45-3 |
| Nambari ya CAT | RF-PI395 |
| Hali ya Hisa | Katika Hisa, Uzalishaji Umeongezeka Hadi Tani |
| Mfumo wa Masi | C10H10ClNO |
| Uzito wa Masi | 195.65 |
| Kiwango cha kuyeyuka | 103.0 hadi 107.0℃ |
| Umumunyifu | Mumunyifu katika Methanoli |
| Chapa | Ruifu Chemical |
| Kipengee | Vipimo |
| Mwonekano | Kijani Kisichokolea hadi Poda ya Manjano Isiyokolea |
| Mbinu za Utambulisho | NMR, HPLC |
| Njia ya Usafi / Uchambuzi | ≥99.0% (HPLC) |
| Kupoteza kwa Kukausha | ≤1.0% |
| Mabaki kwenye Kuwasha | ≤0.50% |
| Uchafu Wowote Mmoja | ≤0.50% |
| Jumla ya Uchafu | ≤1.0% |
| Kiwango cha Mtihani | Kiwango cha Biashara |
| Matumizi | Kati ya Tolvaptan (CAS 150683-30-0), matibabu ya Hyponatremia |
Kifurushi: Chupa, mfuko wa karatasi ya Alumini, Ngoma ya 25kg/Kadibodi, au kulingana na mahitaji ya mteja.
Hali ya Uhifadhi:Hifadhi kwenye vyombo vilivyofungwa mahali pa baridi na kavu;Kinga kutoka kwa mwanga na unyevu.
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) ni ya kati katika usanisi wa Tolvaptan (CAS 150683-30-0).Tolvaptan ni mpinzani wa kipokezi cha arginine vasopressin V2, anayechaguliwa na anayefanya kazi kwa ushindani na IC50 ya 1.28µM kwa ajili ya kuzuia mkusanyiko wa chembe za chembe za AVP.Tolvaptan hutumiwa kutibu hyponatremia inayohusishwa na kushindwa kwa moyo, cirrhosis, na ugonjwa wa homoni isiyofaa ya antidiuretic.Tolvaptan pia yuko katika majaribio ya kliniki ya haraka ya ugonjwa wa figo ya polycystic.Matibabu na Tolvaptan husababisha kupungua kwa uzito wa mwili haraka na kwa kudumu pamoja na kuongezeka kwa mkojo, inaboresha na/au kuhalalisha sodiamu ya serum kwa wagonjwa wa hyponatremia, hupunguza dalili na dalili za msongamano na huongeza kiu.
![7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate](https://www.ruifuchemical.com/uploads/7-Chloro-1234-tetrahydrobenzobazepin-5-one-CAS-160129-45-3-300x300.jpg)
