Diethylphosphonoacetic Acid CAS 3095-95-2 Purity >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory
Waanzilishi wa Ugavi wa Kemikali wa Ruifu wa Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-moja CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oksi)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oksi)quinazolin-4-AmineCAS 314771-88-5
Jina la Kemikali | Asidi ya Diethylphosphonoacetic |
Visawe | 2-(Diethoxyphosphoryl)asidi ya asetiki;(Diethoxyphosphinyl)asidi ya asetiki;Diethyl Carboxymethylphosphonate;NSC 272281 |
Nambari ya CAS | 3095-95-2 |
Nambari ya CAT | RF-PI2024 |
Hali ya Hisa | Katika Hisa, Uwezo wa Uzalishaji 30MT/Mwezi |
Mfumo wa Masi | (C2H5O)2P(O)CH2CO2H |
Uzito wa Masi | 196.14 |
Kuchemka | 150℃/0.05 mmHg (lit.) |
Msongamano | 1.220 g/mL kwa 25℃ (lit.) |
Kielezo cha Refractive | n20/D 1.445 (lit.) |
Chapa | Ruifu Chemical |
Kipengee | Vipimo |
Mwonekano | Kioevu kisicho na rangi |
Kitambulisho (HPLC) | Muda wa kuhifadhi kilele kikuu kilichopatikana kutoka kwa sampuli ni ndani ya 5% ya sampuli ya marejeleo. |
Njia ya Usafi / Uchambuzi | >99.5% (HPLC) |
Spectrum ya Infrared | Inalingana na Muundo |
Protoni NMR Spectrum | Inalingana na Muundo |
Unyevu (KF) | <0.50% |
Jumla ya Uchafu | <0.50% |
Kiwango cha Mtihani | Kiwango cha Biashara |
Matumizi | Kati ya Afatinib Dimaleate (CAS: 850140-73-7) |
Kifurushi: Chupa ya Fluorinated, 25kg/ Ngoma, au kulingana na mahitaji ya mteja
Hali ya Uhifadhi:Hifadhi kwenye vyombo vilivyofungwa mahali pa baridi na kavu;Kinga kutoka kwa mwanga na unyevu
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Asidi ya Diethylphosphonoacetic (CAS: 3095-95-2), Hufanya kazi kama nucleophile kwa athari za nyongeza za nukleofili kwa usanisi wa epoksidi za alene Kinachomenyuka kwa: Masomo ya stereoselectivity ya mmenyuko wa Staudinger;Uundaji wa enantioselective wa diols kupitia epoxidation na athari za uhamishaji;majibu ya Horner-Wadsworth-Emmons;Upangaji upya wa Ireland-Claisen uliodhibitiwa kwa mbali;athari za Ugi-Dieckmann kwa usanisi wa derivatives ya asidi ya tetramic;Inatumika kutengeneza viunga vya phosphonoester kwa athari za HEW za intramolecular.Asidi ya Diethylphosphonoacetic ni ya kati ya Afatinib Dimaleate (CAS: 850140-73-7).Afatinib Dimaleate iliidhinishwa na Mamlaka ya Chakula na Dawa ya Marekani (FDA) mwaka wa 2013 kwa ajili ya matibabu ya saratani ya mapafu ya seli isiyo ndogo (NSCLC).Hasa, iliidhinishwa kwa wagonjwa wanaowasilisha uvimbe wa NSCLC wa metastatic ambao una vipokezi vya epidermal growth factor (EGFR) exon deletions au exon 21 mutations.Afatinib Dimaleate ni kizuizi shirikishi cha ErbB tyrosine kinases (tyk), ambayo hupunguza uwekaji wa ishara wa ErbB kwa ufungaji usioweza kutenduliwa wa tovuti zinazofunga EGFR tyk.
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