LCZ696 CAS 1426129-50-1 Usafi ≥98.0% (HPLC) ee ≥99.0% Usafi wa Juu wa Kiwanda
Ugavi wa Kibiashara LCZ696 (CAS: 936623-90-4) Viatu Husika:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (chumvi ya hemicalcium) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Mchanganyiko wa Sacubitril na Valsartan CAS: 936623-90-4
| Jina la Kemikali | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Visawe | LCZ696 ya kati |
| Nambari ya CAS | 1426129-50-1 |
| Nambari ya CAT | RF-PI169 |
| Hali ya Hisa | Katika Hisa, Uzalishaji Unaongezeka Hadi Mamia ya Kilo |
| Mfumo wa Masi | C20H25NO3 |
| Uzito wa Masi | 327.42 |
| Chapa | Ruifu Chemical |
| Kipengee | Vipimo |
| Mwonekano | Poda Nyeupe hadi Nyeupe |
| Njia ya Usafi / Uchambuzi | ≥98.0% (HPLC) |
| Enantiomeric Ziada | ee: ≥99.0% |
| Unyevu (KF) | ≤1.0% |
| Dutu Zinazohusiana A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Dutu Husika B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oksidi |
| Dutu Nyingine | ≤1.0% |
| Jumla ya Uchafu | ≤2.0% |
| Kiwango cha Mtihani | Kiwango cha Biashara |
| Matumizi | Kati ya LCZ696 (CAS: 936623-90-4) katika matibabu ya HFrEF |
Kifurushi: Chupa, begi ya karatasi ya Alumini, ngoma ya Cardboard, 25kg/Ngoma, au kulingana na mahitaji ya mteja.
Hali ya Uhifadhi:Hifadhi kwenye vyombo vilivyofungwa mahali pa baridi na kavu;Kinga dhidi ya mwanga, unyevu na kushambuliwa na wadudu.
Mtengenezaji mwenye Usafi wa Juu na Ubora Imara
Ugavi wa Kibiashara LCZ696 (CAS: 936623-90-4) Viatu Husika:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (chumvi ya hemicalcium) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Mchanganyiko wa Sacubitril na Valsartan CAS: 936623-90-4
LCZ696 ni dawa ya majaribio iliyotengenezwa na kampuni ya Novartis Pharmaceutical ya Marekani kwa ajili ya kutibu wagonjwa wenye Shida ya Moyo iliyopunguzwa Sehemu ya Kutoa Ejection (HFrEF).Kushindwa kwa moyo ni ugonjwa unaotishia maisha.Moyo wa mgonjwa hauwezi kusukuma damu ya kutosha kusambaza mwili, na kuonekana dalili za dyspnea, uchovu na uhifadhi wa maji polepole, kisha kuongezeka kwa hatua kwa hatua, kuathiri kwa kiasi kikubwa ubora wa maisha.LCZ696 inaweza kuongeza ulinzi wa asili wa mwili dhidi ya kushindwa kwa moyo, na pia kuongeza kiwango cha peptidi za natriuretic na peptidi nyingine za vasoactive endogenous, na kuzuia mfumo wa renin-angiotensin-aldosterone (RAAS).LCZ696 imechanganywa na Dawa ya Presha ya Novartis (Diovan, jina la kawaida: valsartan) na dawa ya majaribio AHU-377.AHU377 huzuia utaratibu wa peptidi mbili zinazohusika na kupunguza shinikizo la damu.Diovan inaboresha vasodilatation na huchochea mwili kutoa sodiamu na maji.
