Telmisartan CAS 144701-48-4 Purity >99.5% (HPLC) API Factory

Short Description:

Chemical Name: Telmisartan

CAS: 144701-48-4

Purity: >99.5% (HPLC)

Appearance: White or Off-White Crystalline

Angiotensin II Receptor Antagonist

High Quality, Commercial Production

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Product Detail

Product Tags

Description:

Ruifu Chemical Supply Telmisartan Intermediates With High Purity
Telmisartan CAS 144701-48-4
Methyl 2-(p-Tolyl)benzoate CAS 114772-34-8
2-(p-Tolyl)benzoic Acid CAS 7148-03-0
Telmisartan Benzimidazole Acid CAS 152628-03-0
Telmisartan Methyl Ester CAS 528560-93-2
Methyl 2-[4-(Bromomethyl)phenyl]benzoate CAS 114772-38-2
Methyl 4-(Butyrylamino)-3-Methyl-5-Nitrobenzoate CAS 152628-01-8
2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9

Chemical Properties:

Chemical Name	Telmisartan
Synonyms	4'-[[4-Methyl-6-(1-Methyl-1H-Benzimidazol-2-yl)-2-Propyl-1H-Benzimidazol-1-yl]methyl]biphenyl-2-Carboxylic Acid; 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-Benzimidazol]-1'-yl)methyl]-[1,1'-Biphenyl]-2-Carboxylic Acid
CAS Number	144701-48-4
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C33H30N4O2
Molecular Weight	514.63
Melting Point	261.0~263.0℃
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White or Off-White Crystalline Powder
Odor	Characteristic
Solubility	Sparingly Soluble in Methylene Chloride, Slightly Souble in Methanol, Parctically Insoluble in Water, Disolves in 1M Solution Hydroxide
IR Identification	Should Correspond to the RS Infrared Absorption
HPLC Identification	Retention Time of Major Peak Should Correspond to RS
Purity / Analysis Method	>99.5% (HPLC)
Loss on Drying	<1.00%
Residue on Ignition	<0.10%
Related Substances
Telmisartan Related Compound A	<0.10%
Telmisartan Amide	<0.10%
Telmisartan Related Compound B	<0.10%
Telmisartan Diacide	<0.10%
Telmisartan Tert-Butyl Ester	<0.20%
Telmisartan Unknown Impurity	<0.20%
Unspecified Impurity	<0.10%
Total Impurities	<1.00%
Residual Solvents
Methanol	<0.30%
Ethanol	<0.50%
Methylene Dichloride	<0.06%
n-Hexane	<0.029%
Acetic Acid Ethyl Ester	<0.50%
Toluene	<0.089%
Acetic Acid	<0.50%
Heavy Metals	<10ppm
Arsenic (As)	<1.00ppm
Lead (Pb)	<1.00ppm
Cadmium (Cd)	<1.00ppm
Particle Size	D90 Not More Than 15μm
Bulk Density (g/cc)	0.11~0.20
Tapped Density (g/cc)	0.22~0.30
Residual Pesticide	Negative
Total Plate Count	<1000cfu/g
Yeast & Mold	<100cfu/g
E. Coli	Negative
Salmonella	Negative
Test Standard	Enterprise Standard; USP 41 Standard
Usage	API

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

Application:

Telmisartan (CAS: 144701-48-4) is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. Telmisartan is a new type of blood pressure drugs, is used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Telmisartan was originally formulated by the German pharmaceutical company Boehringer Ingelheim; it earned the German patent EP502,314 in 1991, was first approved to enter the American market in November 1998, and then entered German, Philippines, Australian, Belgium, British, and other markets.