Tenofovir Disoproxil Fumarate CAS 202138-50-9 Assay 98.0%~102.0% API Factory

Short Description:

Chemical Name: Tenofovir Disoproxil Fumarate

CAS: 202138-50-9

Appearance: White or Almost White Powder

Assay: 98.0%~102.0% (on anhydrous basis)

A nucleotide reverse transcriptase inhibitor used to treat HIV and Chronic Hepatitis B.

High Quality, Commercial Production

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Product Detail

Product Tags

Description:

Commercial Supply Tenofovir Related Intermediates:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl Isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5

Chemical Properties:

Chemical Name	Tenofovir Disoproxil Fumarate
Synonyms	Tenofovir DF; Bis(POC)-PMPA Fumarate; GS 4331 Fumarate
CAS Number	202138-50-9
CAT Number	RF-API106
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C23H34N5O14P
Molecular Weight	635.52
Melting Point	113.0 to 115.0℃
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White or Almost White Powder
Identification A	IR Spectrum Conforms to Reference Standard
Identification B	The retention time of the major peak from the sample solution corresponds to that of the standrd solution,as obtained in the test
Assay	98.0%~102.0% (on anhydrous basis)
Water	≤1.0%
Fumaric Acid	17.5%~19.0%
Residue on Ignition	≤0.20%
Heavy Metals	≤20ppm
Chloromethyl Isopropyl Carbonate	≤0.15%
Related Substances
Tenofovir	≤0.15%
Adenine	≤0.15%
Tenofovir Isoproxi Monoester	≤1.0%
Tenofovir Disoproxil Ethyl Ester	≤0.15%
Tenofovir Isopropyl Isoproxil	≤0.30%
Tenofovir Disoproxil Carbamate	≤0.15%
Tenofovir Disproxil	≤0.15%
Any Single Impurity	≤0.10%
Total Impurities	≤2.0%
Test Standard	Enterprise Standard
Usage	API

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

Advantages:

FAQ:

Application:

Tenofovir Disoproxil Fumarate (CAS: 202138-50-9), a prodrug of tenofovir (Trade name: Viread) developed by Gilead Sciences, is a kind of nucleotide-analogues antiretroviral drugs, taking effect through acting as the reverse transcriptase inhibitors[nRTIs], which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. It should be noted that it is the first nucleotide reverse transcriptase inhibitor that has ever used for the treatment of HIV infection. Tenofovir Disoproxil Fumarate is converted to tenofovir in vivo, which is an acyclic nucleoside phosphonate[nucleotide] analog of adenosine 5'-monophosphate. It is generally used in combination with other kinds of medicine. HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines[called an HIV regimen] every day can help people with HIV live longer, healthier lives. Based on the FDA document, tenofovir disoproxil fumarate can also be for the treatment of chronic hepatitis B virus [HBV] infection in adults and children 12 years of age and older.