4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9 Purity >98.5% (HPLC) Lenvatinib Mesylate Intermediate Factory
Ruifu Chemical Supply Lenvatinib Mesylate Intermediates With High Purity
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Pangalan ng kemikal | 4-Chloro-7-Methoxyquinoline-6-Carboxamide |
Mga kasingkahulugan | 4-Chloro-7-Methoxy-6-Quinolinecarboxamide;Lenvatinib Impurity 12;Lenvatinib Impurity B;Lenvatinib Impurity LFS-B |
Numero ng CAS | 417721-36-9 |
Numero ng CAT | RF-PI1971 |
Katayuan ng Stock | Sa Stock, Kapasidad ng Produksyon 50MT/Taon |
Molecular Formula | C11H9ClN2O2 |
Molekular na Timbang | 236.65 |
Temperatura ng pagkatunaw | >205℃ (dec.) |
Densidad | 1.380±0.060 g/cm3 |
Tatak | Ruifu Chemical |
item | Mga pagtutukoy |
Hitsura | Puti-Puti hanggang Mapusyaw na Dilaw na Pulbos |
Kadalisayan / Paraan ng Pagsusuri | >98.5% (HPLC) |
Pagkawala sa Pagpapatuyo | <0.50% |
Nalalabi sa Ignition | <0.50% |
Kabuuang mga Dumi | <1.50% |
Proton NMR Spectrum | Naaayon sa Istraktura |
Pamantayan sa Pagsubok | Enterprise Standard |
Paggamit | Intermediate ng Lenvatinib Mesylate (CAS: 857890-39-2) |
Package: Bote, Aluminum foil bag, 25kg/Cardboard Drum, o ayon sa pangangailangan ng customer
Kondisyon ng Imbakan:Mag-imbak sa mga selyadong lalagyan sa malamig at tuyo na lugar;Protektahan mula sa liwanag at kahalumigmigan
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Ang 4-Chloro-7-Methoxyquinoline-6-Carboxamide (CAS: 417721-36-9) ay pangunahing ginagamit bilang intermediate ng Lenvatinib Mesylate (CAS: 857890-39-2).Binuo ng Eisai Inc., ang lenvatinib mesylate ay isang vascular endothelial growth factor receptor (VEGF) inhibitor na may aktibidad laban sa VEGF subtypes 1, 2, at 3 at inaprubahan ng FDA noong 2015 para sa paggamot ng differentiated thyroid cancer na alinman sa lokal paulit-ulit, metastatic, o progresibo at hindi tumugon sa paggamot sa radioactive iodine.Noong Mayo 2016, inaprubahan ng FDA ang gamot bilang kumbinasyong therapy na may everolimus para sa paggamot ng advanced na renal cell carcinoma.Dahil ang VEGF (at fibroblast growth factor receptors, na kilala bilang FGFRs) ay naisip na gumaganap ng isang papel sa cardiovascular signaling pathways, ang VEGF2R at FGFR inhibition ay naisip na mga mekanismo sa likod ng pangunahing side effect ng lenvatinib mesylate, na hypertension.
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4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 4...
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4-Amino-3-Chlorophenol CAS 17609-80-2 Lenvatini...
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4-Amino-3-Chlorophenol Hydrochloride CAS 52671-...
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Lenvatinib Mesylate Intermediate CAS 15568-85-1...
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Lenvatinib Mesylate Intermediate CAS 205448-65-...
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Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8...
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