Diethylphosphonoacetic Acid CAS 3095-95-2 Purity >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory
Ruifu Chemical Supply Intermediates ng Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-isang CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5
Pangalan ng kemikal | Diethylphosphonoacetic Acid |
Mga kasingkahulugan | 2-(Diethoxyphosphoryl)acetic Acid;(Diethoxyphosphinyl)acetic Acid;Diethyl Carboxymethylphosphonate;NSC 272281 |
Numero ng CAS | 3095-95-2 |
Numero ng CAT | RF-PI2024 |
Katayuan ng Stock | Sa Stock, Kapasidad ng Produksyon 30MT/Buwan |
Molecular Formula | (C2H5O)2P(O)CH2CO2H |
Molekular na Timbang | 196.14 |
Punto ng pag-kulo | 150 ℃/0.05 mmHg (lit.) |
Densidad | 1.220 g/mL sa 25 ℃ (lit.) |
Repraktibo Index | n20/D 1.445 (lit.) |
Tatak | Ruifu Chemical |
item | Mga pagtutukoy |
Hitsura | Walang kulay na likido |
Pagkakakilanlan (HPLC) | Ang oras ng pagpapanatili ng pangunahing peak na nakuha mula sa sample ay nasa loob ng 5% ng reference na sample. |
Kadalisayan / Paraan ng Pagsusuri | >99.5% (HPLC) |
Infrared Spectrum | Naaayon sa Istraktura |
Proton NMR Spectrum | Naaayon sa Istraktura |
Kahalumigmigan (KF) | <0.50% |
Kabuuang mga Dumi | <0.50% |
Pamantayan sa Pagsubok | Enterprise Standard |
Paggamit | Intermediate ng Afatinib Dimaleate (CAS: 850140-73-7) |
Package: Fluorinated Bottle, 25kg/ Drum, o ayon sa pangangailangan ng customer
Kondisyon ng Imbakan:Mag-imbak sa mga selyadong lalagyan sa malamig at tuyo na lugar;Protektahan mula sa liwanag at kahalumigmigan
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Diethylphosphonoacetic Acid (CAS: 3095-95-2), Nagsisilbing nucleophile para sa nucleophilic addition reactions para sa synthesis ng allene epoxides Reactant para sa: Stereoselectivity studies ng Staudinger reaction;Enantioselective formation ng diols sa pamamagitan ng epoxidation at hydration reactions;Mga reaksyon ng Horner-Wadsworth-Emmons;Remote chelation kinokontrol Ireland-Claisen rearrangement;Ugi-Dieckmann reaksyon para sa synthesis ng tetramic acid derivatives;Ginagamit upang gumawa ng mga phosphonoester intermediate para sa intramolecular HEW reactions.Ang Diethylphosphonoacetic Acid ay isang intermediate ng Afatinib Dimaleate (CAS: 850140-73-7).Ang Afatinib Dimaleate ay inaprubahan ng US Food and Drug Administration (FDA) noong 2013 para sa paggamot ng non-small cell lung cancer (NSCLC).Sa partikular, ito ay naaprubahan para sa mga pasyente na nagpapakita ng metastatic NSCLC tumor na naglalaman ng epidermal growth factor receptor (EGFR) exon deletions o exon 21 mutations.Ang Afatinib Dimaleate ay isang covalent inhibitor ng ErbB tyrosine kinases (tyk), na nagpapababa sa pag-sign ng ErbB sa pamamagitan ng hindi maibabalik na pagbubuklod ng EGFR tyk binding sites.
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