Triisopropylsilyl Chloride (TIPSCl) CAS 13154-24-0 Purity >99.0% (GC) Factory

Triisopropylsilyl Chloride (TIPSCl) (CAS: 13154-24-0), Silicon Compounds, Silane Coupling Agents. It is mainly used as a basic intermediate in the synthesis of organic silicon materials and a blocking agent for silicone oil or silicone rubber. These triisopropylchlorosilanes can be used as raw materials for preparing functional silanes or silane coupling agents. In the reaction with organometallic compounds, the chlorine atoms of triisopropylchlorosilane are replaced by corresponding organic groups to form organochlorosilanes or organofunctional silanes. Triisopropylsilyl Chloride is an important sterically hindered organosilicon protective agent, which is mainly used to protect various types of hydroxyl groups, especially in polyfunctional hydroxyl compounds, which can be selectively protected and deprotected. It is very important to synthesize nucleosides, nucleotides and carbohydrates. Triisopropylchlorosilane is a good hydroxyl protecting agent, and its silanization reaction is carried out in a slight excess of imidazole solution. The acid hydrolytic stability of the protected intermediate is between TBDMS and TBDPS and the alkaline hydrolytic stability is higher than the former two. Triisopropylsilyl Chloride has found new applications as a blocking group. It has been utilized to prepare blocked derivatives of hydroxy compounds. Derivatization of substrates is accomplished efficiently in DMF containing a slight molar excess of imidazole. Blocked intermediates exhibited acidic hydrolytic stability intermediate between that of a Tert-butyldimethylchlorosilane and Tert-butyldiphenyl chlorosilane derivatives. Greater stability was obtained with Triisopropylchlorosilane under basic conditions. Triisopropylsilyl Chloride is used as a silylating agent in neucleotide synthesis. It is used as an intermediate in the manufacture of chemical substances such as pharmaceuticals and in organic synthesis.