Lapatinib Intermediate CAS 231278-84-5 Soflik >98,0% (HPLC)
Kimyoviy nomi | 5-[4-[3-xloro-4-(3-ftorbenziloksi)anilino]-6-quinazolinil]furan-2-karboksaldegid |
Sinonimlar | Lapatinib Intermediate 3;5-[4-[[3-Xloro-4-[(3-fluorofenil)metoksi]fenil]amino]-6-Kinazolinil]-2-Furankarboksaldegid;5-[4-((3-Xloro-4-((3-Ftorbenzil)oksi)fenil)amino)kinazolin-6-il]-2-Furaldegid |
CAS raqami | 231278-84-5 |
Birja holati | Stokda, ishlab chiqarish hajmi tonnagacha |
Molekulyar formula | C26H17ClFN3O3 |
Molekulyar og'irlik | 473,90 |
Erish nuqtasi | 225,0 dan 235,0 ℃ gacha |
Zichlik | 1,407±0,06 g/sm3 |
Sinishi indeksi | 1.694 |
COA va MSDS | Mavjud |
Kelib chiqishi | Shanxay, Xitoy |
Brend | Ruifu kimyoviy |
Element | Texnik xususiyatlari |
Tashqi ko'rinish | Och sariqdan sariq ranggacha qattiq kukun |
Soflik / Tahlil usuli | >98,0% (HPLC) |
Erish nuqtasi | 225,0 ~ 235,0 ℃ |
Quritishda yo'qotish | <1,00% |
Yonayotganda qoldiq | <0,50% |
Umumiy iflosliklar | <2,00% |
Og'ir metallar (Pb sifatida) | <20ppm |
Sinov standarti | Korxona standarti |
Foydalanish | Intermediate API (CAS 388082-77-7) |
Paket: Shisha, alyuminiy folga sumkasi, 25kg / karton baraban yoki mijozning talabiga binoan
Saqlash holati:Salqin va quruq joyda yopiq idishlarda saqlang;Nur va namlikdan saqlang
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5-[4-[3-Chloro-4-(3-Fluorobenziloksi)anilino]-6-Quinazolinyl]furan-2-Karboxaldegid (CAS: 231278-84-5) API (CAS 388082-77-7) ning oraliq mahsulotidir. ).(CAS 388082-77-7) Britaniya GlaxoSmithKline Co tomonidan ishlab chiqilgan ko'krak bezi saratoniga qaratilgan dori. Bu tirozin kinaz inhibitori bo'lib, inson epidermal o'sish omili 1 va 2 retseptorlari (ErbB1, ErbB2) ning tirozin kinaz faolligini samarali inhibe qila oladi.Ko'krak saratoni hujayralari o'sish signallarini qabul qila olmasligini ta'minlab, turli usullar bilan noyob tarzda harakat qilishi mumkin.Hujayra ichidagi EGFR (ErbB-1) va HER2 (ErbB-2) ATP joylarini inhibe qiladi, o'simta hujayralarining fosforillanishi va faollashishini oldini oladi, EGFR (ErbB-1) va HER2 (ErbB-1) ning bir xilligi va heterojenligi orqali pastga regulyatsiya signallarini bloklaydi. dimerizatsiya.
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