N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Soflik >99,0% (HPLC) Afatinib Dimaleat oraliq zavod tavsiya etilgan rasm

N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Soflik >99,0% (HPLC) Afatinib Dimaleat oraliq fabrikasi

Qisqa Tasvir:

Kimyoviy nomi: N-(3-Chloro-4-Fluorofenil)-7-Fluoro-6-Nitroquinazolin-4-Amin

CAS: 162012-67-1

Soflik: >99,0% (HPLC)

Tashqi ko'rinishi: och sariqdan sariq ranggacha kukun

Afatinib Dimaleatning oraliq mahsuloti (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Mahsulot detali

Tegishli mahsulotlar

Mahsulot teglari

Tavsif:

Afatinibning Ruifu kimyoviy ta'minoti oraliqlari
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hidroksitetrahidrofuran CAS 86087-23-2
(Dimetilamino)atsetaldegid Dietil Asetal CAS 3616-56-6
trans-4-Dimetilaminokrotonik kislota gidroxlorid CAS 848133-35-7
Dietilfosfonoasetik kislota CAS 3095-95-2
7-Ftor-6-Nitrokinazolin-4(1H)-bir CAS 162012-69-3
7-Xloro-6-Nitro-4-Hidroksikinazolin CAS 53449-14-2
N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4-(3-Xloro-4-Ftorofenil)-7-((Tetrahidrofuran-3-il)oksi)kinazolin-4,6-DiaminCAS 314771-76-1
(S) -N-(3-Xloro-4-Fluorofenil)-6-Nitro-7-((Tetrahidrofuran-3-il)oksi)kinazolin-4-aminCAS 314771-88-5

Kimyoviy xossalari:

Kimyoviy nomi	N-(3-Chloro-4-Fluorofenil)-7-Fluoro-6-Nitroquinazolin-4-Amin
Sinonimlar	N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitro-4-Quinazolinamin;(3-Xloro-4-Fluorofenil)(7-Ftor-6-Nitrokinazolin-4-il)amin;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitrokinazolin;Afatinib oraliq A
CAS raqami	162012-67-1
CAT raqami	RF-PI2026
Birja holati	Stokda, ishlab chiqarish hajmi tonnagacha
Molekulyar formula	C14H7ClF2N4O2
Molekulyar og'irlik	336,68
Sezuvchanlik	Havoga sezgir, issiqlikka sezgir
Erish nuqtasi	242,0 ~ 244,0 ℃
Qaynash nuqtasi	489 ℃
Zichlik	1.616
Brend	Ruifu kimyoviy

Texnik xususiyatlari:

Element	Texnik xususiyatlari
Tashqi ko'rinish	Och sariqdan sariq ranggacha kukun
Soflik / Tahlil usuli	>99,0% (HPLC)
Quritishdagi yo'qotish	<0,50%
Yonayotganda qoldiq	<0,20%
Tegishli moddalar
Shaxsiy nopoklik	<0,50%
Umumiy iflosliklar	<1,00%
Og'ir metallar	≤20ppm
Infraqizil spektr	Strukturaga mos keladi
Proton NMR spektri	Strukturaga mos keladi
Sinov standarti	Korxona standarti
Foydalanish	Afatinib Dimaleatning oraliq mahsuloti (CAS: 850140-73-7)

Paket va saqlash:

Paket: Shisha, alyuminiy folga sumkasi, 25kg / karton baraban yoki mijozning talabiga binoan

Saqlash holati:Salqin va quruq joyda yopiq idishlarda saqlang;Nur va namlikdan saqlang

Afzalliklari:

TSS:

Ilova:

N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) Afatinib Dimaleat (CAS: 850140-73-7) sintezidagi oraliq mahsulotdir. .Afatinib Dimaleat Afatinibning tuz shaklidir.Afatinib ikkinchi avlod, og'iz orqali yuboriladigan, tirozin kinazlarning ErbB oilasining qaytarilmas inhibitoridir.Ta'sir mexanizmiAfatinib epidermal o'sish omili retseptorlari (EGFR), inson epidermal o'sish omili retseptorlari (HER) 2 va HER4 ning kinaz domenlariga kovalent bog'lanish orqali ErbB signalizatsiyasini pasaytiradi, bu esa tirozin kinaz avtofosforilatsiyasining qaytarilmas inhibisyoniga olib keladi;shuningdek, HER3 ning transfosforilatsiyasini inhibe qiladi.Afatinib EGFR tirozin kinaz inhibitori (TKI) bo'lmagan kattalardagi mahalliy rivojlangan yoki DefinitionChEBI bilan davolash uchun monoterapiya sifatida tasdiqlangan: afatinibni malein kislotasining ikki molyar ekvivalenti bilan birlashtirish natijasida olingan maleat tuzi.Metastatik kichik hujayrali o'pka saratoni bilan og'rigan bemorlarni birinchi darajali davolash uchun ishlatiladi.