N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Soflik >99,0% (HPLC) Afatinib Dimaleat oraliq fabrikasi
Afatinibning Ruifu kimyoviy ta'minoti oraliqlari
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hidroksitetrahidrofuran CAS 86087-23-2
(Dimetilamino)atsetaldegid Dietil Asetal CAS 3616-56-6
trans-4-Dimetilaminokrotonik kislota gidroxlorid CAS 848133-35-7
Dietilfosfonoasetik kislota CAS 3095-95-2
7-Ftor-6-Nitrokinazolin-4(1H)-bir CAS 162012-69-3
7-Xloro-6-Nitro-4-Hidroksikinazolin CAS 53449-14-2
N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4-(3-Xloro-4-Ftorofenil)-7-((Tetrahidrofuran-3-il)oksi)kinazolin-4,6-DiaminCAS 314771-76-1
(S) -N-(3-Xloro-4-Fluorofenil)-6-Nitro-7-((Tetrahidrofuran-3-il)oksi)kinazolin-4-aminCAS 314771-88-5
Kimyoviy nomi | N-(3-Chloro-4-Fluorofenil)-7-Fluoro-6-Nitroquinazolin-4-Amin |
Sinonimlar | N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitro-4-Quinazolinamin;(3-Xloro-4-Fluorofenil)(7-Ftor-6-Nitrokinazolin-4-il)amin;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitrokinazolin;Afatinib oraliq A |
CAS raqami | 162012-67-1 |
CAT raqami | RF-PI2026 |
Birja holati | Stokda, ishlab chiqarish hajmi tonnagacha |
Molekulyar formula | C14H7ClF2N4O2 |
Molekulyar og'irlik | 336,68 |
Sezuvchanlik | Havoga sezgir, issiqlikka sezgir |
Erish nuqtasi | 242,0 ~ 244,0 ℃ |
Qaynash nuqtasi | 489 ℃ |
Zichlik | 1.616 |
Brend | Ruifu kimyoviy |
Element | Texnik xususiyatlari |
Tashqi ko'rinish | Och sariqdan sariq ranggacha kukun |
Soflik / Tahlil usuli | >99,0% (HPLC) |
Quritishdagi yo'qotish | <0,50% |
Yonayotganda qoldiq | <0,20% |
Tegishli moddalar | |
Shaxsiy nopoklik | <0,50% |
Umumiy iflosliklar | <1,00% |
Og'ir metallar | ≤20ppm |
Infraqizil spektr | Strukturaga mos keladi |
Proton NMR spektri | Strukturaga mos keladi |
Sinov standarti | Korxona standarti |
Foydalanish | Afatinib Dimaleatning oraliq mahsuloti (CAS: 850140-73-7) |
Paket: Shisha, alyuminiy folga sumkasi, 25kg / karton baraban yoki mijozning talabiga binoan
Saqlash holati:Salqin va quruq joyda yopiq idishlarda saqlang;Nur va namlikdan saqlang
![1](https://a395.goodao.net/uploads/15.jpg)
![](https://a395.goodao.net/uploads/23.jpg)
N-(3-Chloro-4-Fluorofenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) Afatinib Dimaleat (CAS: 850140-73-7) sintezidagi oraliq mahsulotdir. .Afatinib Dimaleat Afatinibning tuz shaklidir.Afatinib ikkinchi avlod, og'iz orqali yuboriladigan, tirozin kinazlarning ErbB oilasining qaytarilmas inhibitoridir.Ta'sir mexanizmiAfatinib epidermal o'sish omili retseptorlari (EGFR), inson epidermal o'sish omili retseptorlari (HER) 2 va HER4 ning kinaz domenlariga kovalent bog'lanish orqali ErbB signalizatsiyasini pasaytiradi, bu esa tirozin kinaz avtofosforilatsiyasining qaytarilmas inhibisyoniga olib keladi;shuningdek, HER3 ning transfosforilatsiyasini inhibe qiladi.Afatinib EGFR tirozin kinaz inhibitori (TKI) bo'lmagan kattalardagi mahalliy rivojlangan yoki DefinitionChEBI bilan davolash uchun monoterapiya sifatida tasdiqlangan: afatinibni malein kislotasining ikki molyar ekvivalenti bilan birlashtirish natijasida olingan maleat tuzi.Metastatik kichik hujayrali o'pka saratoni bilan og'rigan bemorlarni birinchi darajali davolash uchun ishlatiladi.
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