Valdecoxib CAS 181695-72-7 Purity >99.5% (HPLC)

Short Description:

Chemical Name: Valdecoxib 

CAS: 181695-72-7

Purity: >99.5% (HPLC)  

Appearance: White or Off-White Powder

API, A Second-Generation COX-2 Inhibitor 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Valdecoxib (CAS: 181695-72-7) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name Valdecoxib 
Synonyms Bextra; SC 65872; Valus; Valz; 4-(5-Methyl-3-Phenyl-4-Isooxazolyl)benzenesulfonamide; 4-(5-Methyl-3-Phenyl-1,2-Oxazol-4-yl)benzenesulfonamide; 4-(5-Methyl-3-Phenylisoxazol-4-yl)benzenesulfonamide 
CAS Number 181695-72-7 
CAT Number RF2833
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C16H14N2O3S 
Molecular Weight 314.36  
Melting Point 162.0~167.0℃
Boiling Point 481.2±55.0℃
Density 1.303±0.06 g/cm3
Sensitive Heat Sensitive
Water Solubility  Insoluble in Water
Solubility  Soluble in Ethanol, Methanol
Storage Temp.  Room Temperature
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White or Off-White Powder
Purity / Analysis Method >99.5% (HPLC) 
Melting Point 162.0~167.0℃
Water (by Karl Fischer) <0.50%
Residue on Ignition <0.20%
Single Impurity <0.30%
Total Impurities <0.50%
Heavy Metals (as Pb) <20ppm
Infrared Spectrum Conforms to Structure
NMR Spectrum Conforms to Structure
Test Standard Enterprise Standard
Usage API, A Second-Generation COX-2 Inhibitor

Package & Storage:

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

Valdecoxib (CAS: 181695-72-7) is a second-generation COX-2 inhibitor, developed as a follow-up to celecoxib for the oral once-daily treatment of osteoarthritis, adult rheumatoid arthritis and menstrual pain. Valdecoxib is approximately 28,000-fold more selective against human recombinant COX-2 than human recombinant COX-1. In an ex viva human whole blood assay, the I&O values against COX-2 and COX-1 were respectively 0.89 PM and 25.4 FM. In animal models, valdecoxib possesses excellent oral activity as an antiinflammatory. In rats, valdecoxib potently inhibited carrageenan footpad edema and adjuvant-induced arthritis. Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in animal models. It is a potent and selective inhibitor of prostaglandin synthesis primarily through inhibition of COX-2. Valdecoxib is used to relieve some symptoms caused by arthritis (rheumatism), such as inflammation, swelling, stiffness, and joint pain. Valdecoxib is approved for the relief of the signs and symptoms of osteoarthritis and adult rheumatoid arthritis and for the treatment of primary dysmenorrhea. Valdecoxib is contraindicated for the treatment of postoperative pain immediately following coronary artery bypass graft surgery. 

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