Wholesale Price China 2 3-Di-O-acetyl-5-deoxy-5-fluorocytidine - 2′-Deoxycytidine CAS 951-77-9 Purity ≥99.0% (HPLC) High Purity – Ruifu

Manufacturer Supply Deoxynucleosides Intermediates with High Purity and Stable Quality

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

2-Deoxycytidine is a cytidine analog. 2′-Deoxycytidine is a deoxyribonucleoside as Eg5 kinesin modulator with apoptosis-inducing and antiproliferative activity.

2-Deoxycytidine prevents DNA methylation by incorporating itself into newly synthesizing DNA strand. 2-Deoxycytidine also binds to DNA methyltransferase irreversibly and hinders its activity. Thus, 2-deoxycytidine was approved as the most efective demethylating agent for the treatment of cancer .

2-Deoxycytidine at clinically achievable and nontoxic concentrations (≥ 100 μmol/L) protected normal bone marrow progenitor cells against the inhibitory effects of co-administered, high concentrations of 3’-azido-3’-deoxythymidine (AZT) (≥ 10 μmol/L). In normal bone marrow mononuclear cells (BMMC), 2-deoxycytidine also significantly corrected AZT-mediated depletion of intracellular thymidine triphosphate and 2-deoxycytidine triphosphate levels. Furthermore, 2-deoxycytidine reduced the intracellular accumulation of AZT triphosphate and its DNA incorporation in BMMC.