I-1-Methyl-3-Pyrrolidinol CAS 13220-33-2 Ubunyulu > 98.0% (GC)

Inkcazelo emfutshane:

Igama leKhemikhali: 1-Methyl-3-Pyrrolidinol

Izithethantonye: 3-Hydroxy-1-Methylpyrrolidine

CAS: 13220-33-2

Ubunyulu: >98.0% (GC)

Imbonakalo: Ulwelo oluMthubi oKhanyayo

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical ngumenzi ohamba phambili we-1-Methyl-3-Pyrrolidinol (3-Hydroxy-1-Methylpyrrolidine) (i-CAS: 13220-33-2) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-1-Methyl-3-Pyrrolidinol,Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	I-1-Methyl-3-Pyrrolidinol
Izithethantonye	N-Methyl-3-Pyrrolidinol;I-3-Hydroxy-1-Methylpyrrolidine;N-Methyl-Pyrrolidin-3-ol;I-N-Methyl-Pyrrolidinyl Utywala;1-Methylpyrrolidin-3-ol
Ubume beStokhwe	Kwi-Stock, iMveliso yoRhwebo
Inombolo yeCAS	13220-33-2
Ifomula yeemolekyuli	C5H11NO
Ubunzima beMolekyuli	101.15 g/mol
Indawo yokubilisa	75℃/12 mmHg
Indawo yokuflasha	71℃
Ukuxinana	0.921 g/mL ku-25℃ (lit.)
Refractive Index n20/D	1.464(lit.)
Inovakalelo	I-Air Sensitive, Hygroscopic
Ukunyibilika	Inyibilika emanzini, iNyibilika kuButywala, iEtere kunye neBenzene
I-COA kunye ne-MSDS	Iyafumaneka
Isampulu	Iyafumaneka
Imvelaphi	Shanghai, China
Uphawu	Ruifu Chemical

Iinkcukacha:

Izinto	ImiGangatho yokuHlola	Iziphumo
Imbonakalo	Ulwelo oluMthubi oluKhanya	Ulwelo oluMthubi oluKhanya
Amanzi nguKarl Fischer	<0.20%	0.15%
Ubunyulu / Indlela yokuHlalutya	>98.0% (GC)	98.57%
Ubuninzi (20℃)	0.920~0,923	Iyahambelana
Refractive Index n20/D	1.463~1.465	Iyahambelana
I-Infrared Spectrum	Ngokungqinelana noLwakhiwo	Iyahambelana
I-1H NMR Spectrum	Ngokungqinelana noLwakhiwo	Iyahambelana
Ukuqukumbela	Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.

13220-33-2 - Indlela yokwenziwa:

13220-33-2 - Indlela yokuLungisa:

Yongeza i-1,2,4-Butanetriol kunye ne-glacial acetic acid kwi-acetic acid kwi-reaction pot, ugxobhoze kwaye ushushu malunga ne-100 ℃, yongeza igesi eyomileyo ye-hydrogen chloride, kwaye usabele kwi-90 ~ 110 ℃ ye-30h, xa isixa esikhulu se-hydrogen chloride saqala kubonakala kwirhasi yomsila, indawo yokugqibela yokusabela ihlolwe kwaye i-hydrogen chloride yamiswa.Emva kokupholisa, izinto eziphathekayo zikhutshwe, zihlanjwe ngesisombululo se-sodium carbonate egcweleyo, kwaye ifakwe kwi-distillation phantsi koxinzelelo oluncitshisiweyo, kunye ne-120 ukuya kwi-135 ℃.(12.6 ukuya kwi-13. 3kPa) iqhezu, mna, i-1,4-Dichloro-2-Butanol i-oily oil, isivuno se-50% ~ 60%.
Ukuhamba ngebhayisikili isisombululo samanzi se-1,4-Dichloro-2-Butanol kunye ne-Methylamine yongezwa kwi-cyclization pot, kwaye ishushu kwi-120 ℃.Ngaphantsi kokufudumala okuvaliweyo, kwaye ukusabela kwavuselelwa i-10h.Emva kokupholisa, i-sodium hydroxide eyomeleleyo yongezwa, kwaye ityuwa ye-inorganic egayiweyo yahluzwa.Uluhlu lweoyile lwahlulwa kwaye luphantsi kwe-vacuum distillation, kunye neqhezu le-76-85℃.(2.1 kPa) yaqokelelwa ukuba ibe yimveliso egqityiweyo.Ukukhutshwa kwe-aqueous layer kunye ne-benzene kwakhona kuvelisa inxalenye ye-1-Methyl-3-Pyrrolidinol.Isivuno sasimalunga nama-60%.
3. Iinkqubo eziphambili:
3.1 I-substituted reaction process: lawula ixesha lokuphendula kwaye ubone isiphelo sokuphendula
3.2 Inkqubo ye-vacuum distillation ye-1,4-Dichloro-2-Butanol: lawula i-vacuum degree ye-vacuum distillation kunye nobushushu beqhezu
3.3 Inkqubo yokusabela ngebhayisekile: lawula ubushushu bokusabela kunye nexesha
3.4 1-Methyl-3-Pyrrolidinol vacuum distillation inkqubo: ukulawula vacuum degree of vacuum distillation kunye neqhezu lobushushu
4. Amanqaku okulawula umgangatho:
Inqaku lokulawula umgangatho 1: 1,2,4-Butanetriol umgangatho wezinto ezibonakalayo
Inqaku lesi-2 lolawulo lomgangatho: Umgangatho womgangatho wolawulo oluphakathi lokusabela ngebhayisikile
Inqaku lokulawula umgangatho 3: 1,4-Dichloro-2-Butanol umgangatho ophakathi womgangatho
Inqaku lokulawula umgangatho 4: I-1-Methyl-3-Pyrrolidinol igqibile umgangatho womgangatho wemveliso

13220-33-2 - Indlela yoVavanyo:

Umxholo wokufuma: Thatha le mveliso kwaye uyivavanye ngokwendlela yokumisela ukufuma (Indlela yokuQala ye-A yeSihlomelo Ⅷ M, i-2010 Edition ye-People's Republic of China Pharmacopoeia).Isiqulatho sokufuma asiyi kuba ngaphezu kwe-0.2%.
Uxinaniso olunxulumeneyo: Uxinaniso olunxulumeneyo lwale mveliso (Isihlomelo VI A seCandelo II, uhlelo luka-2010) yi-0.920 ~ 0.923
I-Refractive Index: Isalathiso se-refractive sale mveliso (Isihlomelo VI F seCandelo II le-2010 edition) yi-1.463 ~ 1.465
Ukumiselwa komxholo: Umxholo we-1-Methyl-3-Pyrrolidinol akufanele ube ngaphantsi kwe-98.0% nge-chromatography yegesi (Isihlomelo Ⅴ E, iCandelo II, i-2010 edition).
Ikholamu: I-Capillary kwi-silica enyibilikisiweyo ye-SPB-5, i-diameter yangaphakathi 0.32mm, ubude be-30m
T Isitofu: 300℃
FID: 320℃
Ikholamu ye-T: 80℃ imizuzu emi-5, ukuya kwi-200℃ kwi-5℃/min, emva koko kwi-200℃ kwi-7 min.
Umthwali: I-Helium kwi-1 ml / min
Ukwahlula Umlinganiselo: 100:1
Isitofu: 1 microliter
Isisombululo sovavanyo: chitha i-200mg yesampuli phantsi kohlalutyo kwi-10ml ye-methanol.Tofa i-1 microliter.I-1μl yafakwa kwi-chromatograph yegesi ukurekhoda ichromatogram.Umxholo we-1-Methyl-3-Pyrrolidinol ubalwa ngendlela yokulinganisa indawo ephezulu.

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

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13220-33-2 - Umngcipheko kunye noKhuseleko:

Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko
36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumula kunye nesikhumba.
Inkcazelo yoKhuseleko
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
WGK eJamani 3
Ikhowudi yeHS 2933990099

13220-33-2 - Isicelo:

I-1-Methyl-3-Pyrrolidinol (i-3-Hydroxy-1-Methylpyrrolidine) (i-CAS: i-13220-33-2) isetyenziswe njenge-organic synthesis intermediate, esetyenziswa njenge-pharmaceutical intermediate kwi-industry ye-pharmaceutical industry.