(1S,2R)-(-)-1-Amino-2-indanol CAS 126456-43-7 Ubunyulu ≥99.0% EE ≥99.0% Indinavir Sulfate Intermediate
Umenzi onoMgangatho oPhezulu kunye neXabiso loKhuphiswano
Ubonelelo ngezoRhwebo lwe-Indinavir Sulfate (CAS: 157810-81-6) abaPhakathi abaNxulumeneyo:
(1R,2S)-(+)-1-Amino-2-indanol CAS: 136030-00-7
(1S,2R)-(-)-1-Amino-2-indanol CAS: 126456-43-7
| Igama leMchiza | (1S,2R)-(-)-1-Amino-2-indanol |
| Izithethantonye | (1S,2R)-(-)-1-Amino-2-hydroxyundan |
| Inombolo yeCAS | 126456-43-7 |
| Inombolo yeCAT | RF-CC120 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C9H11NO |
| Ubunzima beMolekyuli | 149.19 |
| Ukunyibilika (Ukunyibilika ngaphakathi) | IMethanol |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMhlophe ukuya koMthubi |
| Ukujikeleziswa okuthe ngqo [α]D20 | -47.0°~ -42.0° (C=1,MeOH) |
| Indawo yokunyibilika | 115.0～121.0℃ |
| Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
| Ilahleko ekomisweni | ≤0.50% |
| Ukufuma (KF) | ≤0.50% |
| EE | ≥99.0% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Indinavir Sulfate (CAS: 157810-81-6) Abaphakathi |
Iphakheji: Ibhotile, Igubu lekhadibhodi, 25kg / Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi (1S,2R)-(-)-1-Amino-2-indanol (CAS: 126456-43-7) kunye nomgangatho ophezulu.(1S,2R)-(-)-1-Amino-2-indanol (CAS: 126456-43-7) yindawo ephakathi ngokuqhelekileyo kwi-synthesis ye-Indinavir Sulfate (CAS: 157810-81-6).
I-Indinavir Sulfate (i-CAS: 157810-81-6) (MK-639) yi-protease inhibitor esetyenziswa njengenxalenye yonyango olusebenzayo lwe-antiretroviral (HAART) ukunyanga ukusuleleka kwi-HIV kunye ne-AIDS.I-MK-639 ibonakala inomsebenzi obalulekileyo we-antiviral onxulumene nedosi kwaye inyamezeleke kakuhle.I-Indinavir sisithinteli esinamandla se-HIV reverse transcriptase.Ivelisa iziphumo ebezingalindelekanga ezixhaphakileyo kuzo zonke ii-protease inhibitors kwaye inokuvelisa nephrolithiasis, urolithiasis, kunye nokungasebenzi kakuhle kwezintso okanye ukusilela kwezintso.Le ngxaki yenzeka rhoqo ebantwaneni (malunga ne-30%) kunabantu abadala (malunga ne-10%) kwaye inokuncitshiswa ngokusela ubuncinane i-1.5 L yamanzi yonke imihla.Imiphumo eyongezelelweyo yecala ibandakanya i-hyperbilirubinemia engabonakaliyo, i-alopecia, i-toenails e-ingrown, kunye ne-paronychia.I-anemia ye-Hemolytic ayifane yenzeke.I-Rifampin akufuneki inikwe kunye ne-indinavir.
