I-2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4 Ubunyulu > 99.5% (HPLC) iTipiracil Hydrochloride Intermediate Factory
Ubonelelo lwabavelisi, uMgangatho oPhezulu kunye neXabiso loKhuphiswano
I-Tipiracil Hydrochloride (CAS: 183204-72-0) abaPhakathi abaNxulumeneyo
I-6-(Chloromethyl)uracil CAS: 18592-13-7
I-6-(Hydroxymethyl)uracil CAS: 22126-44-9
I-2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4
| Igama leMchiza | I-2-Amino-1-Pyrroline Hydrochloride |
| Izithethantonye | I-3,4-Dihydro-2H-Pyrrol-5-Amine Hydrochloride;I-2-Aminopyrrolidine HCl |
| Inombolo yeCAS | 7544-75-4 |
| Inombolo yeCAT | RF-PI1838 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C4H8N2·HCl |
| Ubunzima beMolekyuli | 120.58 |
| Indawo yokunyibilika | 171.0 ukuya 175.0℃ |
| Inovakalelo | Hygroscopic |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo oMhlophe | Umgubo oMhlophe |
| Ubunyulu / Indlela yokuHlalutya | >99.5% (HPLC) | 99.8% |
| Ukungcola Okukodwa Okukhulu | <0.50% | 0.09% |
| Isiqulatho samanzi (KF) | <0.50% | 0.45% |
| Proton NMR Spectrum | Iyahambelana noLwakhiwo | Iyahambelana |
| Umgangatho woVavanyo | Umgangatho woShishino | |
| Ukusetyenziswa | Phakathi kweTipiracil Hydrochloride (CAS: 183204-72-0) | |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
I-2-Amino-1-Pyrroline Hydrochloride (i-CAS: 7544-75-4) i-heterocyclic organic compound, enokusetyenziswa njenge-pharmaceutical intermediate.I-2-Amino-1-Pyrroline Hydrochloride iphakathi kweTipiracil Hydrochloride (CAS: 183204-72-0) kunyango lweCancer Rectal.I-Tipiracil Hydrochloride yi-inhibitor enamandla kunye nokhuphiswano lwe-thymidine phosphorylase (TPase) enexabiso le-IC50 le-35 nM kwi-TPase ye-placental yabantu.Ikhetha i-TPase ngaphezu kwezinye i-pyrimidine-metabolizing enzymes (IC50s => 1 mM ye-UPase, OPRTase, TK, kunye neDPDAse).I-TPI inqanda i-phosphorolysis kunye nokuthotywa kwe-trifluorothymidine, i-cytotoxic nucleoside, kwisifuba somntu kunye neesampuli ze-colon carcinoma tumor.Ukulawulwa komlomo kwe-TPI (12.5-50 mg / kg) kuphucula umsebenzi wokulwa ne-tumor we-trifluorothymidine kwi-mouse AZ-521 imodeli yomhlaza wesisu xenograft.Iifomyula eziqulethe i-TPI zisetyenziselwe ukunyanga umhlaza we-metastatic colorectal.
