I-2-Chloro-5-Iodobenzoic Acid CAS 19094-56-5 Empagliflozin Intermediate Assay ≥99.0% (HPLC)
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
Igama leKhemikhali: 2-Chloro-5-Iodobenzoic Acid
CAS: 19094-56-5
Igama leMchiza | I-2-Chloro-5-Iodobenzoic Acid |
Inombolo yeCAS | 19094-56-5 |
Inombolo yeCAT | RF-PI438 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C7H4ClIO2 |
Ubunzima beMolekyuli | 282.46 |
Ukunyibilika | Inyibilika kwiMethanol |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | IiCrystals eziMhlophe okanye eziMthubi |
Indlela yoVavanyo / yoHlahlelo | ≥99.0% (HPLC) |
Indawo yokunyibilika | 161.0 ~ 163.0℃ |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.20% |
Ukungcola ngokupheleleyo | ≤1.0% |
Iintsimbi ezinzima | ≤20ppm |
Intsalela yokunyibilika | I-Ethanol |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weMpagliflozin (CAS: 864070-44-0) |
I-2-Chloro-5-Iodobenzoic Acid (CAS 19094-56-5) Indlela yokwenziwa
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-2-Chloro-5-Iodobenzoic Acid (i-CAS: 19094-56-5) ingasetyenziswa njenge-pharmaceutical intermediate kwi-synthesis ye-Empagliflozin (CAS: 864070-44-0).I-Empagliflozin (igama lorhwebo iJardiance) sisithinteli se-sodium glucose co-transporter-2 (SGLT-2), kwaye ibangela iswekile esegazini ukuba ikhutshelwe zizintso kwaye ikhutshwe kumchamo.Ngo-Agasti 1, i-2014, i-Food and Drug Administration (FDA) ivume ngokusemthethweni ichiza lonyango lwe-2 yesifo sikashukela, ukuphucula nokulawula i-glucose yegazi yabantu abadala.I-Empagliflozin lichiza lesithathu le-SGLT-2 elithintelayo elivunywe yi-FDA.Amanye amachiza amabini e-SGLT-2 inhibitor, i-Canagliflozin kunye ne-Dapagliflozin, eye-Johnson Pharmaceuticals, i-AstraZeneca kunye ne-Bristol-Myers Squibb ngokulandelanayo, ivunywe yi-FDA ngoNovemba 2013 kunye noJanuwari 2014 ngokulandelelanayo.
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