I-2-Chloradenine CAS 1839-18-5 Assay ≥98.0% (HPLC) Factory
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
Igama leKhemikhali: 2-Chloradenine
CAS: 1839-18-5
Igama leMchiza | 2-Chloradenine |
Izithethantonye | I-6-Amino-2-Chloropurine;Cladribine EP Ukungcola B |
Inombolo yeCAS | 1839-18-5 |
Inombolo yeCAT | RF-PI513 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C5H4ClN5 |
Ubunzima beMolekyuli | 169.57 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mthubi ukuya kumgubo oMhlophe |
Indlela yoVavanyo / yoHlahlelo | ≥98.0% (HPLC) |
Indawo yokunyibilika | ≥300℃ |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.50% |
Iintsimbi ezinzima (njenge Pb) | ≤0.001% |
Ukungcola ngokupheleleyo | ≤2.0% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weClofarabine (CAS: 123318-82-1), uCladribine (CAS: 4291-63-8) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-2-Chloradenine (i-CAS: 1839-18-5) isetyenziswa kakhulu njenge-intermediate yeClofarabine (CAS: 123318-82-1), iCladribine (CAS: 4291-63-8) kunye nezinye ii-API.I-Clofarabine iyinoveli ye-purine nucleoside anticancer yamachiza iphuhliswe ngempumelelo yi-Top10 biopharmaceutical company yase-United States-Genzyme Corporation.Ngomhla wama-28 kuDisemba, i-2004 i-US Food and Drug Administration (FDA) yasebenzisa i-fast-track yokuvunywa kwe-clofarabine kwisicelo kubantwana abane-refractory okanye i-relapsed acute lymphocytic leukemia.I-Cladribine (2-chloro-2′-deoxyadenosine) yi-adenosine deaminase-resistant analogue ye-deoxyadenosine.Ichiza linoluhlu olubanzi lomsebenzi we-in vitro ngokuchasene ne-lymphoid kunye ne-myeloid neoplasms.
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