I-2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6 iLinagliptin ePhakathi yoBusulungekileyo ≥99.0% (HPLC)
Ubonelelo loMvelisi iLinagliptin kunye neMidiya eNxulumeneyo:
I-Linagliptin CAS 668270-12-0
ILinagliptin yoMzali iNyucleus ePhakathi CAS 853029-57-9
8-Bromo-3-Methylxanthine CAS 93703-24-3
I-8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine CAS 666816-98-4
I-2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6
(R)-3-(Boc-Amino)piperidine CAS 309956-78-3
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
1-Bromo-2-Butyne CAS 3355-28-0
Igama leMchiza | I-2-(Chloromethyl) -4-Methylquinazoline |
Izithethantonye | ILinagliptin ePhakathi A |
Inombolo yeCAS | 109113-72-6 |
Inombolo yeCAT | RF-PI498 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C10H9ClN2 |
Ubunzima beMolekyuli | 192.64 |
Ukuxinana | 1.251 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMthubi oMthubi ukuya kwiPowder emdaka |
Isazisi A | Isampulu ye-IR kufuneka ihambelane ne-spectrum eqhelekileyo |
Isazisi B | Ixesha lokugcinwa kwencopho yomgaqo wesampulu kufuneka ihambelane nomgangatho |
Ukunyibilika | Inyibilika kwiMethylene Chloride;Ayinyibilikiyo emanzini |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Indawo yokunyibilika | 60.0 ukuba 65.0℃ |
Amanzi (KF) | ≤0.50% |
Intsalela kwi-Ignition | ≤0.50% |
Izinto ezinxulumeneyo | |
Ukungacoceki Okukodwa | ≤0.30% |
Ukungcola ngokupheleleyo | ≤1.0% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Esiphakathi kwiLinagliptin (CAS: 668270-12-0) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-2-(Chloromethyl) -4-Methylquinazoline (i-CAS: 109113-72-6) isetyenziswe njengendawo ephakathi yokulungiswa kweLinagliptin (CAS: 668270-12-0), kunye nokungcola kwayo.I-Linagliptin, ethengiswa phantsi kwegama lebrendi iTradjenta phakathi kwezinye, liyeza elisetyenziselwa ukunyanga isifo seswekile sohlobo lwesi-2. Ngokuqhelekileyo ayithandwa kakhulu kune-metformin kunye ne-sulfonylureas njengonyango lokuqala.Isetyenziswa kunye nokuzilolonga kunye nokutya.Ayikhuthazwa kuhlobo lwe-1 yeswekile.Isebenza ngokwandisa imveliso ye-insulin kunye nokunciphisa ukuveliswa kweglucagon yi-pancreas.I-Linagliptin yamkelwa ukuba isetyenziswe kwezonyango e-United States ngo-2011. I-Linagliptin inamandla kakhulu, ikhetha i-dipeptidyl peptidase-4 (DPP-4) inhibitor ene-IC50 ye-1 nM.