I-2-Hydroxy-5-Methylpyridine CAS 1003-68-5 Ubunyulu ≥99.0% iPirfenidone Intermediate Factory
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
Igama leKhemikhali: 2-Hydroxy-5-Methylpyridine
CAS: 1003-68-5
| Igama leMchiza | I-2-Hydroxy-5-Methylpyridine |
| Izithethantonye | 5-Methyl-2(1H)-Pyridinone;I-2-Hydroxy-5-Picoline;I-6-Hydroxy-3-Picoline;5-Methyl-2-Pyridinol |
| Inombolo yeCAS | 1003-68-5 |
| Inombolo yeCAT | RF-PI549 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C6H7NO |
| Ubunzima beMolekyuli | 109.13 |
| Indawo yokunyibilika | 183.0 ukuya 187.0℃ (lit.) |
| Ukunyibilika | Inyibilika kwiMethanol |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Okumhlophe-kuMhlophe ukuya koMthubi wePowder yeCrystalline |
| Ubunyulu | ≥99.0% |
| Isiqulatho sokufuma (KF) | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.50% |
| Nakuphi na Ukungacoceki Okukodwa | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤1.00% |
| Izinyibilikisi ezishiyekileyo | |
| n-Butanol | ≤0.30% |
| I-Ethanol | ≤0.30% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Umbindi wePirfenidone (CAS: 53179-13-8) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
I-2-Hydroxy-5-Methylpyridine (i-CAS: 1003-68-5) isetyenziswe njenge-pharmaceutical intermediate ye-Pirfenidone (CAS: 53179-13-8).I-Pirfenidone (PFD) luhlobo lwenoveli ye-pyridine ketones ene-wide-spectrum anti-fibrotic effect, ekwazi ukuthintela kunye nokubuyisela umva ukubunjwa kwe-fibrosis kunye nesiva.Yangena kwimarike eShionogi, eJapan ngo-2008 kwaye yamkelwe yi-US yokutya kunye noLawulo lweziyobisi.Lichiza lokuqala eliye ladlula kwisigaba sesi-III solingo lwezonyango (kubandakanya ukuphindaphinda, ukungakhethi, kunye nolawulo lwe-placebo) olubonise ukusebenza kwalo ekunyangeni i-idiopathic pulmonary fibrosis (IPF);ngaphezu koko, iyeza lisebenza kakuhle ekunyangeni izifo ezithile zefibrotic ezifana ne-renal interstitial fibrosis kunye ne-liver fibrosis.
