I-2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5 iTolvaptan ePhakathi yeFactory ePhakamileyo
Ubonelelo loMvelisi, uMgangatho oPhezulu, iMveliso yoRhwebo
I-Tolvaptan kunye nabaPhakathi abaNxulumeneyo:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
I-4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
I-2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
| Igama leMchiza | I-2-Methyl-4-Nitrobenzoic Acid |
| Izithethantonye | I-4-Nitro-o-Toluic Acid;I-4-Nitro-2-Methylbenzoic Acid |
| Inombolo yeCAS | 1975-51-5 |
| Inombolo yeCAT | RF-PI397 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C8H7NO4 |
| Ubunzima beMolekyuli | 181.15 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Phantse uMhlophe okanye uMthubi oMthubi wePowder |
| 1H-NMR | Ngokungqinelana noLwakhiwo |
| Ubunyulu / Indlela yokuHlalutya | ≥98.0% (HPLC) |
| Indawo yokunyibilika | 153.0 ~ 156.0℃ |
| Ukufuma (KF) | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤2.0% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kweTolvaptan (CAS 150683-30-0) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-2-Methyl-4-Nitrobenzoic Acid (i-CAS 1975-51-5) isetyenziswe njenge-pharmaceutical intermediate kwi-synthesis ye-Tolvaptan (i-CAS 150683-30-0).I-Tolvaptan yinto ekhethiweyo, ekhuphisanayo ye-arginine i-vasopressin receptor 2 i-antagonist kunye ne-IC50 ye-1.28μM yokuvinjelwa kwe-AVP-induced platelet aggregation.I-Tolvaptan isetyenziselwa ukunyanga i-hyponatremia (amanqanaba e-sodium ephantsi yegazi) ehambelana nokungaphumeleli kwentliziyo, i-cirrhosis, kunye ne-syndrome ye-antidiuretic hormone engafanelekanga (SIADH).I-Tolvaptan yavunywa yi-US Food and Drug Administration ngoMeyi 19, 2009, kwaye ithengiswa yi-Otsuka Pharmaceutical Co. phantsi kwegama lezorhwebo elithi Samsca.
![7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3 Tolvaptan Intermediate](https://www.ruifuchemical.com/uploads/7-Chloro-1234-tetrahydrobenzobazepin-5-one-CAS-160129-45-3-300x300.jpg)
