I-2-Methyltryptamine CAS 2731-06-8 Ubunyulu > 99.0% (HPLC) Panobinostat Umgangatho oPhakamileyo weFactory
Ubonelelo loMvelisi ngoMgangatho oPhezulu, iMveliso yoRhwebo
Igama leKhemikhali: 2-Methyltryptamine CAS: 2731-06-8
Igama leMchiza | 2-Methyltryptamine |
Izithethantonye | 2-Methylindole-3-Ethylamine;2-(2-Methyl-1H-indol-3-yl) ethanamine;3-(2-Aminoethyl)-2-Methylindole |
Inombolo yeCAS | 2731-06-8 |
Inombolo yeCAT | RF-PI1480 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C11H14N2 |
Ubunzima beMolekyuli | 174.25 |
Indawo yokunyibilika | 106.0 ukuba 110.0℃ |
Indawo yokubilisa | 177℃/1.5mmHg(lit.) |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umdaka oqinileyo |
Ubunyulu / Indlela yokuHlalutya | >99.0% (Ummandla weHPLC) |
1-HNMR | Ukungqinelana Nolwakhiwo |
Ilahleko ekomisweni | <1.00% |
Ukungacoceki Okukodwa | <0.50% |
Ukungcola ngokupheleleyo | <1.00% |
Iintsimbi ezinzima (njenge Pb) | <20ppm |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | abaPhakathi bamayeza;I-Panobinostat ePhakathi |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-2-Methyltryptamine (i-CAS: i-2731-06-8) yinto ephambili yokuqala kwi-synthesis ye-Panobinostat (LBH589) (i-CAS: 404950-80-7).I-Panobinostat yi-inhibitor enamandla yazo zonke i-histone deacetylases (i-HDACs), kunye namaxabiso e-Ki ukusuka kwi-0.6 ukuya kwi-31 nM ye-HDAC1-11.Ngesi senzo, kukhokelela kwi-acetylation yoluhlu lweeproteni zeselula, ezikhokelela ekubanjweni komjikelo weeseli kunye ne-apoptosis kwiiseli zomhlaza.I-Panobinostat yi-HDAC inhibitor yokuqala eyavunywa yi-FDA kunyango lwe-myeloma emininzi.I-Panobinostat ithengiswa njenge-Farydak, isetyenziswe ngokudibanisa ne-Bortezomib (CAS: 179324-69-7) kunye ne-Dexamethasone (i-CAS: i-50-02-2) ukunyanga i-myeloma ephindaphindiweyo emva kokunyangwa kwangaphambili kunye ne-Bortezomib kunye ne-immunomodulator.
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