2′,3′-Di-O-acetyl-5′-deoxy-5-fluorocytidine CAS 161599-46-8 Ubunyulu ≥99.0% I-Capecitabine Intermediate Factory
Unikezelo lwezoRhwebo abaPhakathi abaNxulumeneyo neCapecitabine:
I-5-Fluorocytosine CAS: 2022-85-7
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine CAS: 161599-46-8
I-1,2,3-Tri-O-acetyl-5-deoxy-β-D-ribofuranose CAS: 62211-93-2
Capecitabine CAS: 154361-50-9
Igama | 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine |
Inombolo yeCAS | 161599-46-8 |
Inombolo yeCAT | RF-PI176 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C13H16FN3O6 |
Ubunzima beMolekyuli | 329.28 |
Umqathango Omele Uphetshwe | Ubushushu Bubuthathaka |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMhlophe okanye otyheli |
Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.0% |
Indawo yokunyibilika | 178.0 ~ 193.0℃ |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.10% |
Ukufuma (KF) | ≤1.0% |
Isivavanyi | ≥99.0% |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Intermediate of Capecitabine (CAS: 154361-50-9) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Capecitabine (i-CAS: 154361-50-9) luhlobo olutsha lweyeza lomlomo lwe-fluorinated pyrimidine.I-Capecitabine yaphuhliswa yi-Roche Pharmaceuticals, kwaye igama layo lezorhwebo yi-Xeloda.I-Capecitabine inokutshintsha kwi-vivo ibe yi-5- FU, i-anti-metabolizim fluorine pyrimidine deoxynucleoside carbamate ichiza elijolise kwiiseli zomhlaza ukuvimbela ukwahlukana kweeseli kunye nokuphazamisa i-RNA kunye neprotheni synthesis.Iziphumo zayo zibophelelwe kakhulu kwinqanaba le-TP enzyme yokubonakaliswa kwi-neoplastic tissue kunye ne-DPD enzyme kwi-vivo expression.Ifanelekile njengonyango olongezelelweyo kwizigulane ezinomhlaza webele we-primary okanye we-metastatic ongakhange uphendule kwi-paclitaxel okanye i-anthracycline antibiotics.Njengechiza le-anticancer, lisetyenziswa kakhulu ukunyanga umhlaza webele okwinqanaba eliphambili okanye we-metastatic, kunye nakunyango lomhlaza wemiphunga ongeyonxalenye encinci, umhlaza wepancreatic, umhlaza wesinyi, umhlaza we-rectal, umhlaza we-colon, umhlaza wesisu, kunye namanye amathumba aqinileyo. .