I-2,3-Dihydrobenzofuran CAS 496-16-2 Ramelteon Intermediate Purity > 99.0% (GC)

Inkcazelo emfutshane:

Igama leKhemikhali: 2,3-Dihydrobenzofuran

Izithethantonye: Coumaran;2,3-Dihydrobenzo[b]furan

CAS: 496-16-2

Ubunyulu: >99.0% (GC)

Imbonakalo: Ulwelo olucacileyo olungenambala okanye olutyheli

Umbindi weRamelteon (CAS: 196597-26-9)

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

UMvelisi oPhambili kunye noMboneleli, abaPhakathi beRamelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-enye CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
I-Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	2,3-Dihydrobenzofuran
Izithethantonye	Coumaran;2,3-Dihydro-2,3-Benzofuran;2,3-Dihydrobenzo[b]furan;2,3-Dihydro-1-Benzofuran
Inombolo yeCAS	496-16-2
Inombolo yeCAT	RF2884
Ubume beStokhwe	KwiSitokhwe, Umthamo weMveliso iiToni ezingama-20 ngenyanga
Ifomula yeemolekyuli	C8H8O
Ubunzima beMolekyuli	120.15
Indawo yokunyibilika	-21℃
Indawo yokubilisa	188.0~189.0℃ (ilayiti.)
Indawo yokuflasha	66℃
Ukunyibilika	Utywala: Bunyibilika
Inqaku Lengozi	Iyacaphukisa
I-TSCA	Ewe
Ikhowudi ye-HS	29329995
Ugcino Temp.	Itywinwe kwindawo eyomileyo, ubushushu beGumbi
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Ulwelo olucacileyo olungenambala okanye olutyheli
Ubunyulu / Indlela yokuHlalutya	>99.0% (GC)
Amanzi (nguKarl Fischer)	<0.50%
Ubuninzi (20℃)	1.065~1.085
Refractive Index n20/D	1.547~1.551
Ukungacoceki Okukodwa	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Proton NMR Spectrum	Iyahambelana neSakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	I-Pharmaceutical Intermediate ye-Ramelteon (CAS: 196597-26-9)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile eneFluorinated, 25kg/Drum, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

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Isicelo:

I-2,3-Dihydrobenzofuran (i-CAS: i-496-16-2) isetyenziswe ngokubanzi kwi-synthesis ye-tricyclic compounds kwaye iphinda ibe yinto ephakathi kwezinto ezibonakalayo zokwenziwa kweziyobisi ezibalulekileyo.I-2,3-Dihydrobenzofuran ingasetyenziselwa njengendawo ephakathi kweRamelteon (CAS: 196597-26-9).I-Ramelteon, ethengiswa njenge-Rozerem yi-Takeda Pharmaceuticals eMntla Melika, i-arhente yokulala ebophelela ngokukhethekileyo kwi-MT1 kunye ne-MT2 receptors kwi-nucleus ye-suprachiasmatic (SCN), endaweni yokubophelela kwi-GABAA receptors, njengamachiza afana ne-zolpidem.Nangona kunjalo ayibonakali ikhawulezisa ukuqalisa kokulala okanye ubungakanani bokulala umntu abufumanayo.Ivunyiwe yi-US Food and Drug Administration (FDA) yokusetyenziswa kwexesha elide.I-Ramelteon ayibonisi nakuphi na ukubophelela okuxabisekileyo kwi-GABAA receptors, ehambelana ne-anxiolytic, i-myorelaxant, kunye nemiphumo ye-amnesic.Ngokungafaniyo nonyango oluninzi lokungalali olujolise kwi-GABA (g-aminobutyric acid) i-receptor complex, i-ramelteon i-agonist ye-melatonin receptor.Ngokukodwa, inokukhethwa okuphezulu kwe-MT1 kunye ne-MT2 subtypes, eziye zabandakanyeka ekugcinweni kwe-circadian rhythms, phezu kwe-MT3 receptor ejongene neminye imisebenzi ye-melatonin.I-2,3-Dihydrobenzofuran iphinda isetyenziswe kwi-synthesis ye-antitumor agents benzofuran sulfonylureas, i-HIV protease inhibitor amino acid hydroxyethylenesulfonyl, i-matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, njl.