2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5 Remdesivir Intermediate COVID-19

Inkcazelo emfutshane:

Igama: 2,3,5-Tri-O-benzyl-D-ribonolactone

Izithethantonye: 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone

CAS: 55094-52-5

Imbonakalo: Mhlophe ukuya phantse kuMhlophe

Ubunyulu: ≥99.0%

Umbindi we-Remdesivir (CAS 1809249-37-3) COVID-19

Umgangatho ophezulu, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

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Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo loMvelisi i-Remdesivir kunye nabaPhakathi abaNxulumeneyo nabanoMgangatho oPhezulu
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Iipropati zeMichiza:

Igama leMchiza	2,3,5-Tri-O-benzyl-D-ribonolactone
Izithethantonye	2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone;I-Remdesivir ePhakathi
Inombolo yeCAS	55094-52-5
Inombolo yeCAT	RF-PI301
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	C26H26O5
Ubunzima beMolekyuli	418.49
Indawo yokunyibilika	54.0-55.0℃
Imeko yoGcino	Ubushushu beGumbi
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umthubi okanye oMhlophe Okuqinileyo
Ukunyibilika	I-Soluble kwi-CH2Cl2 kunye ne-Insoluble kwi-H2O
I-NMR kunye ne-MS	Kufuneka Uthobele
Ukuchongwa	I-IR kunye ne-TLC
Ukufuma	≤1.0%
Intsalela kwi-Ignition	≤0.50%
Nakuphi na Ukungacoceki komntu	≤0.50%
Iintsimbi ezinzima	≤50ppm
I-HPLC (210nm)	≥99.0%
I-HPLC (ELSD)	≥99.0%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Umbindi we-Remdesivir (CAS 1809249-37-3)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

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Isicelo:

I-2,3,5-Tri-O-benzyl-D-ribonolactone (i-CAS 55094-52-5) yi-Remdesivir ephakathi.I-Remdesivir (CAS 1809249-37-3) lichiza eliyinoveli le-antiviral kudidi lwe-nucleotide analogs, elisetyenziswa kunyango lwe-COVID-19.I-Remdesivir (GS-5734) yi-analogue ye-antiviral nucleoside enoveli enqanda intsholongwane ye-murine hepatitis (MHV) ene-EC50 efanayo ne-SARS-CoV kunye ne-MERS-CoV.IiCoronavirus (CoVs) ziintsholongwane ezinemisonto enye ye-RNA ezosulela uluhlu olubanzi lwezilwanyana.Ebantwini, ii-CoVs zaqatshelwa njengesiqhelo ezibangela ukubanda kunye nenyumoniya de kwavela i-acute acute breathing syndrome (SARS-CoV) ngo-2002 kunye ne-Middle East Respiratory Syndrome coronavirus (MERS-CoV) ngo-2012 ukusuka kwimithombo yezoonotic.I-Remdesivir yi-monophosphoramidate prodrug ye-C-adenosine nucleoside analogue GS-441524.Kwiiseli ezibambezelekayo zobuchopho (DBT) ezosulelwe yi-MHV, i-GS-5734 inqande i-MHV ngokunamandla ngaphezu kwe-GS-441524, kunye ne-GS-5734 EC50 ye-0.03 M. Ngaphezu koko, ixabiso le-EC50 limiselwe emva konyango nge-GS-441524 kunye ne-GS-5734 kunye ne-GS-5734 kwiinkcubeko ze-SARS-CoV- kunye ne-MERS-CoV-ezosulelwe umgaqo womoya woluntu we-epithelial cell (HAE).