2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0 Ubunyulu ≥99.5% (GC) Sitagliptin Phosphate Monohydrate Intermediate
Ubonelelo ngeSitagliptin Phosphate Monohydrate Eziyeleleneyo neziPhakathi:
I-Sitagliptin API CAS 486460-32-6
I-Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
I-Sitagliptin Triazole Hydrochloride CAS 762240-92-6
I-Sitagliptin Phosphate Monohydrate ePhakathi CAS 486460-21-3
Igama leMchiza | 2,4,5-Trifluorophenylacetic Acid |
Inombolo yeCAS | 209995-38-0 |
Inombolo yeCAT | RF-PI1191 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C8H5F3O2 |
Ubunzima beMolekyuli | 190.12 |
Indawo yokunyibilika | 121.0 ukuba 125.0℃ |
Ukunyibilika | Inyibilika kwiMethanol |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kwi-Off-White Powder |
Ubunyulu / Indlela yokuHlalutya | ≥99.5% (GC) |
Ukufuma (KF) | ≤0.50% |
Intsalela kwi-Igniton | ≤0.50% |
Ukungcola ngokupheleleyo | ≤0.50% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi weSitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-2,4,5-Trifluorophenylacetic Acid (CAS: 209995-38-0) iphakathi kwe-Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9).I-Sitagliptin Phosphate (STG) isetyenziselwa ukuphatha uhlobo lwe-DM ye-2 kuba iphucula ulawulo lwe-glycemic ngokunyusa amanqanaba e-hormone ye-incretin esebenzayo, i-GLP-1 (peptide-1) kunye ne-GIP (i-glucose-exhomekeke kwi-insulinotropic peptide).Ukusetyenziswa kwezi incretins kwiiseli ze-β-pancreatic kubangela ukwanda kwamanqanaba e-cyclic adenosine monophosphate (cAMP) kunye ne-intracellular calcium, kunye ne-glucose exhomekeke kwi-insulin secretion (2).Eli chiza le-hypoglycemic leleklasi entsha ebizwa ngokuba yi-dipeptidyl peptidase IV inhibitors.I-STG yavunywa yi-FDA kwi-2006.