(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2 Darunavir Intermediate High Purity
Ubonelelo loMvelisi kwiiMveliso eziNxulumene neDarunavir:
Darunavir CAS 206361-99-1
I-Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Igama leMchiza | (2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane |
| Izithethantonye | (2S,3S)-3-(Boc-Amino)-1,2-Epoxy-4-Phenylbutane;(2S,3S)-3-(tert-Butoxycarbonylamino)-1,2-epoxy-4-phenylbutane;I-Darunavir ePhakathi |
| Inombolo yeCAS | 98737-29-2 |
| Inombolo yeCAT | RF-PI286 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C15H21NO3 |
| Ubunzima beMolekyuli | 263.33 |
| Ukunyibilika | Ayinyibilikiyo emanzini.Inyibilika kwiMethanol, iChloroform |
| Imeko yokuthumela ngenqanawa | Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
| Ukuchongwa (HPLC) | Ukuchongwa kungqinwe yi-HPLC |
| Indawo yokunyibilika | 123.0 ~ 128.0℃ |
| Ukufuma (KF) | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.20% |
| Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
| I-Chlorohydrin (HPLC) | ≤0.20% |
| I-Chloromethyl Ketone | ≤0.10% |
| Okunye Ukungcola Okukodwa | ≤0.20% |
| Ukungcola ngokupheleleyo | ≤1.0% |
| Ukungacoceki kweChiral | ≤0.30% |
| Iintsimbi ezinzima | ≤20ppm |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Umbindi weDarunavir (CAS 206361-99-1) HIV-1 Protease Inhibitor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, Igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi we (2S,3S) -1,2-Epoxy-3- (Boc-Amino) -4-Phenylbutane (CAS: 98737-29-2) kunye nomgangatho ophezulu. , i-intermediate ngokuqhelekileyo kwi-synthesis ye-Darunavir (CAS 206361-99-1) kunye ne-Darunavir Ethanolate (i-CAS 635728-49-3).
I-Darunavir (CAS 206361-99-1) luhlobo olutsha lwe non peptide anti retroviral protease inhibitors kunyango lwe-AIDS.Yenziwa okokuqala lisebe le-Johnson pharmaceutical Iceland, iTibotec.Yeyona bioavailability iphezulu kwii-6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir kunye ne-ABT378/r).Isebenza ngokuthintela ukwakheka kwamasuntswana entsholongwane amatsha nasele ekhulile kumphezulu weeseli ezisulelekileyo kwaye inqanda iprotease yentsholongwane.Xa imveliso isetyenziswa ixesha elide, ngesiqhelo inokwehlisa intsholongwane yentsholongwane kagawulayo egazini, inyuse isibalo seeseli ze-CD4, inciphise ithuba lokosulelwa yi-HIV, iphucule umgangatho wobomi kwaye yandise ubomi.Ibafanele abantu abadala abosulelwe yintsholongwane kagawulayo kodwa abanayo impembelelo kusetyenziso lwamachiza asele ekhona ee-antiretroviral.Ichiza kufuneka lidityaniswe nokusetyenziswa kweedosi eziphantsi ze-ritonavir okanye ezinye ii-antiretroviral agents, ukuze kuphuculwe ukusebenza kakuhle.
