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3-[3-(Trifluoromethyl)phenyl] -1-Propanol CAS 78573-45-2 Cinacalcet Hydrochloride Intermediate Purity>99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-3-[3- (Trifluoromethyl) phenyl] -1-Propanol (CAS: 78573-45-2) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, amancinci kunye nenani elikhulu elikhoyo.Thenga i-3-[3-(Trifluoromethyl)phenyl] -1-Propanol,Please contact: alvin@ruifuchem.com
| Igama leMchiza | 3-[3-(Trifluoromethyl)phenyl] -1-Propanol |
| Izithethantonye | 3-[3-(Trifluoromethyl)phenyl]propanol;3-(3'-Trifluoromethylphenyl)propanol;3-(3-(Trifluoromethyl)phenyl)propan-1-ol;3-(Trifluoromethyl)benzene propanol |
| Ukungcola | USP Cinacalcet Related Compound E |
| Ubume beStokhwe | Kwisitokhwe, isikali soRhwebo |
| Inombolo yeCAS | 78573-45-2 |
| Ifomula yeemolekyuli | C10H11F3O |
| Ubunzima beMolekyuli | 204.19 g/mol |
| Indawo yokubilisa | 60℃/1.13mmHg(lit.) |
| Indawo yokuflasha | 105℃ |
| Ugcino Temp. | Indawo epholileyo kunye neyomileyo |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Udidi | AbaPhakathi bamayeza |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | AbunaMbala ukuya kuLwelo oluKhanyayo | Iyahambelana |
| Amanzi nguKarl Fischer | <0.50% | 0.07% |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) | 99.60% |
| Refractive Index n20/D | 1.462~1.466 | Iyahambelana |
| Ubuninzi (20℃) | 1.212~1.216 | Iyahambelana |
| I-Infrared Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| I-1 H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha | |
| Isicelo | Phakathi kweCinacalcet Hydrochloride (CAS: 364782-34-3) | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
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Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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I-3--[3- (Trifluoromethyl) phenyl] -1-Propanol (CAS: 78573-45-2) yindawo ephakathi kwi-synthesis yeCinacalcet Hydrochloride (CAS: 364782-34-3).I-Cinacalcet yinto yokuqala yokungena kwiklasi entsha yee-agent zonyango ezibizwa ngokuba yi-calcimimetics.Yasungulwa njengonyango lomlomo lwe-hyperparathyroidism yesibini (SHPT) kwizigulana ezinesifo sezintso ezingapheliyo kwi-dialysis kunye ne-hypercalcemia kwizigulane ezine-parathyroid carcinoma.I-SHPT inxulumene nokunyuka kwehomoni ye-parathyroid (PTH), ebangelwa ngamanqanaba aphantsi e-serum ye-calcium ngenxa yokungaphumeleli kwezintso ukucima i-phosphorous emzimbeni kunye nokungakwazi ukuvelisa inani elaneleyo le-vitamin D. Iziphumo zokunyuka kwe-PTH zibandakanya ukuvuselela umsebenzi we-osteoclastic, i-cortical bone resorption kunye ne-marrow fibrosis.Imfihlo ye-PTH ilawulwa ngokuyinhloko yi-calcium-sensing receptor (CaR), efumaneka kumphezulu weseli eyintloko ye-parathyroid gland.I-Calcimimetics ibophelela kwi-CaR kunye nokwandisa uvakalelo lwe-CaR kwi-calcium e-extracellular, ngaloo ndlela ivumela ukuba isebenze kumanqanaba angaphantsi kwe-serum calcium.Ngenxa yoko, phambi kwezi arhente, amanqanaba aphantsi e-calcium e-endogenous kwizigulane ezinokungaphumeleli kwezintso ziyakwazi ukwenza impembelelo yokunciphisa i-PTH secretion.I-Parathyroid carcinoma nayo inxulunyaniswa namanqanaba aphezulu e-PTH, aqhutywa ngumsebenzi ozimeleyo we-parathyroid gland kwaye emva koko ikhokelele kwi-hypercalcemia.Nangona uqhaqho loqhaqho lolona nyango luphambili lokunyanga i-hypercalcemia kwizigulana ze-parathyroid carcinoma, i-calcimimetics ibonelela ngolunye utyando olungelulo kwizigulana ezinokusilela kwe-parathyroidectomy, i-metastatic parathyroid carcinoma, okanye umngcipheko omkhulu wotyando.
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