I-3-Ethynylaniline CAS 54060-30-9 Ucoceko > 99.0% (GC) Erlotinib Hydrochloride Intermediate
Umvelisi ohamba phambili kunye nomthengisi we-Erlotinib Hydrochloride Intermediates
I-Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis (2-Methoxyethoxy)-3H-Quinazolin-4-enye CAS 179688-29-0
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Igama leMchiza | 3-Ethynylaniline |
Izithethantonye | 3-Aminophenylacetylene |
Inombolo yeCAS | 54060-30-9 |
Inombolo yeCAT | RF-PI2241 |
Ubume beStokhwe | Kwi-Stock, iMveliso yeMveliso ye-50MT / ngenyanga |
Ifomula yeemolekyuli | C8H7N |
Ubunzima beMolekyuli | 117.15 |
Inovakalelo | Ubuthathaka bomoya, ukuKhanya okungevayo |
Indawo yokubilisa | 120℃/20 mmHg |
Ukunyibilika kwamanzi | Ayinyibilikiyo emanzini |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Ulwelo oluKhanyayo ukuya kwiBrown |
Ubunyulu / Indlela yokuHlalutya | >99.0% (GC) |
Amanzi nguKarl Fischer | <0.50% |
Intsalela kwi-Ignition | <0.20% |
Ukungcola ngokupheleleyo | <1.00% |
Ubunzima obuthile (20/20℃) | 1.041~1.048 |
Refractive Index n20/D | 1.614~1.6195 |
I-Infrared Spectrum | Iyahambelana neSakhiwo |
Proton NMR Spectrum | Iyahambelana neSakhiwo |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Phakathi kwezamayeza;I-Erlotinib Hydrochloride ePhakathi |
Iphakheji: Ibhotile eneFluorinated, 25kg/Drum, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
I-3-Ethynylaniline, eyaziwa nangokuthi i-3-Aminophenylacetylene (i-CAS: 54060-30-9) isetyenziswe njenge-pharmaceutical intermediate.I-3-Ethynylaniline iphakathi kwe-Erlotinib Hydrochloride (CAS: 183319-69-9).I-Erlotinib Hydrochloride yi-molecule encinci ye-tyrosine kinase inhibitor esebenza ngokuguquguqukayo kwi-epidermal growth receptors, i-hydrochloride ye-erlotinib, ichiza elijoliswe kwi-molecular.I-US Food and Drug Administration (FDA) ivume i-erlotinib (i-Tarceva) idityaniswe ne-gemcitabine njengonyango lokuqala lomhlaza we-pancreatic kunye ne-metastatic.Isetyenziswa ikakhulu njengonyango lodidi lwesibini okanye lwesithathu kumhlaza wemiphunga okwinqanaba eliphezulu okanye i-metstatic non-small cell lung (NSCLC) kunye nonyango lomhlaza wepancreatic.Isetyenziswe njenge-tyrosine inhibitor yonyango lwe-NSCLC.I-Erlotinib Hydrochloride, i-quinazoline efunyenwe kwi-molecule encinci ye-molecule ye-epidermal growth receptor (EDGFR) i-tyrosine kinase, yavunywa ngoNovemba, i-2004, kunyango lwe-Advanced or Metastatic non-small cell lung cancer.