I-3-Nitrophthalic Anhydride CAS 641-70-3 Pomalidomide Intermediate Purity>98.0% (HPLC)
I-Ruifu Chemical ngumenzi ohamba phambili we-3-Nitrophthalic Anhydride (CAS: 641-70-3) enomgangatho ophezulu, ophakathi kwePomalidomide (CAS: 19171-19-8).I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga i-3-Nitrophthalic Anhydride,Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-3-Nitrophthalic Anhydride |
| Izithethantonye | I-3-Nitrophthalic Acid Anhydride;4-Nitro-2-Benzofuran-1,3-Dione;4-Nitroisobenzofuran-1,3-Dione;4-Nitro-1,3-isobenzofurandione;Ukungacoceki kwePomalidomide A |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 641-70-3 |
| Ifomula yeemolekyuli | C8H3NO5 |
| Ubunzima beMolekyuli | 193.11 g/mol |
| Indawo yokunyibilika | 161.0 ukuya 165.0℃ |
| Inovakalelo | Ukungenwa kukufuma |
| Ukunyibilika kwamanzi | Inokubola Emanzini |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Umthubi oKhanyayo ukuya kwetyheli onaliti yeCrystal okanye umgubo weCrystalline | Iyahambelana |
| Indawo yokunyibilika | 161.0 ~ 165.0℃ | 163.0 ~ 165.0℃ |
| Ilahleko ekomisweni | <0.50% | 0.10% |
| Ubunyulu / Indlela yokuHlalutya | >98.0% (HPLC) | 98.85% |
| I-Infrared Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| I-1H NMR Spectrum | Ngokungqinelana noLwakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
| Isicelo | Phakathi kwePomalidomide (CAS: 19171-19-8) | |
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Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko
36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumula kunye nesikhumba.
Inkcazelo yoKhuseleko
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
I-S37/39 - Nxiba iiglavu ezifanelekileyo kunye nokukhusela amehlo / ubuso
WGK eJamani 3
FLUKA BRAND F IIKHOWUDI 10-21
TSCA Ewe
Ikhowudi yeHS 2917399090
I-3-Nitrophthalic Anhydride (i-CAS: 641-70-3) isetyenziswe njengendawo ephakathi yePomalidomide (CAS: 19171-19-8).NgoFebruwari 2013, i-US FDA yavuma i-Pomalidomide yonyango lwe-myeloma emininzi (MM) kwizigulane ezinenkqubela phambili yesifo emva kokufumana ezinye iindlela zonyango zomhlaza.I-Pomalidomide yi-4-amino analog ye-thalidomide ene-potency ephuculweyo kunye neprofayili ye-toxicity ephuculweyo.I-Pomalidomide kunye ne-thalidomide zisebenzisa imiphumo yazo ngokuguqulwa kwe-immunity, inhibition of angiogenesis, ukuphazamiseka kwethambo / i-tumor microenvironment, kunye nokuvinjelwa kweprotheni ye-cereblon.I-Pomalidomide ithintele ngokunamandla ukwanda kwe-vitro kwiindidi zeeseli ze-MM zabantu, i-IC50 ~ 10 nM, ngelixa i-thalidomide ibonise phantse i-inhibition ukuya kwi-100 μM.Kwiimodeli ze-tumor ye-mouse ye-mouse, i-50 mg / kg imilinganiselo yemihla ngemihla ye-pomalidomide ibangele uthintelo oluphawulweyo lokukhula kwethumba emva kweentsuku ze-15 zonyango kunye nokuhlehla ngokupheleleyo kwiiveki ezi-3-6 ngokuchasene nolawulo olunyangwa nge-thalidomide kwidosi efanayo.I-Pomalidomide ilungiselelwe ngokucondelwa kwe-3-Nitrophthalic Anhydride kunye ne-3-Aminopiperidine-2,6-Dione elandelwa yi-catalytic hydrogenation yeqela le-nitro.
