3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9 Olaparib Intermediate Factory
Ukucoceka okuphezulu, iMveliso yoRhwebo
I-Olaparib kunye nabaPhakathi abaNxulumeneyo:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
I-2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Igama leMchiza | 3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid |
| Izithethantonye | I-Dimethyl 3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonate |
| Inombolo yeCAS | 61260-15-9 |
| Inombolo yeCAT | RF-PI453 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C10H11O5P |
| Ubunzima beMolekyuli | 242.17 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMhlophe okanye ophantse wamhlophe |
| Ubunyulu | ≥98.0% |
| Ukufuma (KF) | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤2.0% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kwe-Olaparib (CAS: 763113-22-0) PARP-Inhibitor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid (CAS: 61260-15-9), phakathi kwe-Olaparib (CAS: 763113-22-0).I-Olaparib luhlobo lwenoveli ye-poly ADP-ribose polymerase (PARP) inhibitors, kuquka i-PARP1, i-PARP2, kunye ne-PARP3.I-PARP ilamla indlela yokulungisa i-DNA edlala indima ebalulekileyo ekulungiseni umonakalo we-DNA kunye ne-apoptosis, ngoko ke i-olaparib ijolise ngokukodwa kwindlela yokulungisa i-DNA yeseli ekujoliswe kuyo ukulungiswa kwe-DNA kwaye ithathe imiphumo ngokuhlasela ubuthathaka obubalulekileyo beeseli zomhlaza ezithwala utshintsho kwi-BRCA1 kwaye I-BRCA2.Ngenxa yolu matshini, inokusetyenziswa kunyango lokugcinwa kwezigulana ezinomhlaza we-ovarian ophinda-phindayo abanomhlaza webele (BRCA) uguquko kunye nokuba novelwano kwiplatinam.
