4-[(1-Pyrrolidinylsulfonyl)methyl]aniline CAS 334981-10-1 Ubunyulu>99.0% (HPLC) I-Almotriptan Aniline Precursor Factory
I-Ruifu Chemical Supply Almotriptan Malate Intermediates:
Almotriptan Malate CAS 181183-52-8
I-1-((4-Hydrazinylbenzyl)sulfonyl)pyrrolidine Hydrochloride CAS 334981-11-2
4-[(1-Pyrrolidinylsulfonyl)methyl]aniline CAS 334981-10-1
1-[(4-Nitrophenylmethyl)sulfonyl]pyrrolidine CAS 340041-91-0
I-4-Chlorobutyraldehyde Diethyl Acetal CAS 6139-83-9
Igama leMchiza | 4-[(1-Pyrrolidinylsulfonyl)methyl]aniline |
Izithethantonye | 1-[(4-Aminobenzyl)sulfonyl]pyrrolidine;Almotriptan Aniline Precursor |
Inombolo yeCAS | 334981-10-1 |
Inombolo yeCAT | RF-PI1948 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C11H16N2O2S |
Ubunzima beMolekyuli | 240.32 |
Indawo yokunyibilika | 170.0 ukuya 176.0℃ |
Ukuxinana | 1.31 |
Ukunyibilika | Inyibilika kancinane kwiToluene |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMthubi ukuya kuMthubi |
Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
Ilahleko ekomisweni | <0.50% |
Intsalela kwi-Ignition | <0.50% |
Ukungahlambuluki Okukodwa okuphezulu | <0.50% |
Ukungcola ngokupheleleyo | <1.00% |
Iintsimbi ezinzima | <20ppm |
I-Infrared Spectrum | Iyahambelana noLwakhiwo |
NMR | Iyahambelana noLwakhiwo |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Almotriptan Aniline Precursor |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-4-[(1-Pyrrolidinylsulfonyl) methyl]aniline (CAS: 334981-10-1) iphakathi ekulungiseleleni i-Almotriptan Malate (CAS: 181183-52-8), i-Almotriptan Aniline Precursor.I-Almotriptan Malate luhlobo lwechiza le-triptan elinokusetyenziswa kunyango lwentloko eqaqambayo.I-Almotriptan iyinxalenye yeziyobisi ezikhethiweyo ze-serotonin receptor agonists.I-Almotriptan inobudlelwane obuphezulu kunye obucacileyo be-serotonin i-5-HT i-receptors, ngakumbi ikhokelela kwi-vascoconstriction ye-brain blood vessel kunye nokuchaphazela ukwabiwa kwakhona kwegazi.Ezi ziphumo zimisa iimpawu zentlungu ekuthunyelweni kwengqondo, kwaye zicinezela ngakumbi ukukhululwa kwezinto ezithile zendalo ezibangela intlungu, isicaphucaphu kunye nezinye iimpawu ze-migraine.Nangona kunjalo, i-Almotriptan ayikuthinteli ukuhlaselwa kwe-migraine.I-Almotriptan, ithengiswe ngo-2000, ineyona ndawo iphezulu ye-oralbioavailability kuzo zonke iitriptan.I-Almotriptan i-metabolized zombini i-MAO-A kunye ne-CYP3A4, ngoko ke ineprofayili yeziphumo ezithandekayo xa ithelekiswa ne-Sumatriptan.