I-4-Benzyl-2-Hydroxymorpholin-3-enye CAS 287930-73-8 Ubunyulu > 99.0% (HPLC) I-Aprepitant Intermediate Factory
Umenzi ophambili kunye nomthengisi
Abaphakathi be-Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-enye CAS 287930-73-8
(R) -1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Igama leMchiza | 4-Benzyl-2-Hydroxymorpholin-3-enye |
| Izithethantonye | 4-Benzyl-2-Hydroxy-Morpholin-3-enye;I-2-Hydroxy-4- (Phenylmethyl) -3-Morpholinone;Ukungcola kwe-Aprepitant 48;Ukungcola kweFosaprepitant 23;I-Aprepitant ePhakathi Ⅱ |
| Inombolo yeCAS | 287930-73-8 |
| Inombolo yeCAT | RF2660 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C11H13NO3 |
| Ubunzima beMolekyuli | 207.23 |
| Indawo yokunyibilika | 134.0 ukuba 138.0℃ |
| Indawo yokubilisa | 441.7±45.0℃ |
| Ukuxinana | 1.292±0.06 g/cm3 |
| Ukunyibilika emanzini | I-DMSO (Kancinci), iMethanol (Kancinci, ishushu) |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe wePowder yeCrystal |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Indawo yokunyibilika | 134.0 ukuba 138.0℃ |
| Amanzi (nguKarl Fischer) | <0.50% |
| Intsalela kwi-Ignition | <0.20% |
| Ukungcola ngokupheleleyo | <1.00% |
| Proton NMR Spectrum | Iyahambelana neSakhiwo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Intermediate of Aprepitant (CAS: 170729-80-3) I-Antiemetic Drug |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
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I-4-Benzyl-2-Hydroxymorpholin-3-enye (i-CAS: 287930-73-8), iphakathi kwe-Aprepitant (CAS: 170729-80-3), isetyenziswe njengeziyobisi ze-antiemetic.I-Aprepitant i-neurokinin-1 (NK-1) i-receptor antagonist kwaye ingamalungu onyango lokuhlanza ngexesha le-chemotherapy yomhlaza.Iqale yaphuhliswa ngempumelelo yiNkampani yeMerck (isiJamani).NgoMatshi ka-2003, i-US Food and Drug Administration yavuma ukuba isetyenziswe kunyango lwe-chemotherapy vomiting.Le mveliso inobudlelwane obuphezulu obukhethiweyo kubantu ngelixa inobudlelwane obuphantsi kwi-serotonin, i-dopamine kunye ne-glucocorticoid receptor affinity.I-Aprepitant, xa idibene ne-5-HT3 receptor inhibitors (efana ne-ondansetron hydrochloride) kunye ne-corticosteroid dexamethasone, inokunciphisa ngakumbi i-cisplatin-induced acute kunye (okanye) i-emesis yokulibaziseka.Ukusebenzisa eli chiza kuphela kunokuba nefuthe lokuthintela.
![(R) -1-[3,5-Bis (trifluoromethyl)phenyl]ethanol CAS 127852-28-2 Ubunyulu> 99.0% (GC) Aprepitant Intermediate](https://www.ruifuchemical.com/uploads/R-1-35-Bistrifluoromethylphenylethanol-CAS-127852-28-2-300x300.jpg)