I-5-Bromo-2-Chloro-4′-Ethoxydiphenylmethane CAS 461432-23-5 iDapagliflozin Intermediate Factory
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
I-Dapagliflozin (CAS: 461432-26-8) IziPhakathi eziNxulumeneyo:
I-5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4
I-5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane CAS 461432-23-5
2,3,4,6-Tetrakis-O-Trimethylsilyl-D-Gluconolactone CAS 32384-65-9
Igama leMchiza | 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane |
Izithethantonye | I-4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)benzene;4-(5-Brom-2-Chlorbenzyl)phenyl-Ethylether;Ukungcola kweDapagliflozin Bromo |
Inombolo yeCAS | 461432-23-5 |
Inombolo yeCAT | RF-PI447 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C15H14BrClO |
Ubunzima beMolekyuli | 325.63 |
Indawo yokunyibilika | 41.0 ukuba 43.0℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMhlophe ukuya kwiPael |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Amanzi (KF) | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.0% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Intermediate ye-Dapagliflozin (CAS: 461432-26-8), uhlobo lwe-II yeswekile |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, Igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-4-Bromo-1-Chloro-2- (4-Ethoxybenzyl)benzene (CAS: 461432-23-5) isetyenziswe njengendawo ephakathi kwi-synthesis ye-Dapagliflozin (CAS: 461432-26-8).I-Dapagliflozin yi-inhibitor enamandla, ekhethiweyo ye-renal sodium-dependent glucose cotransporter 2 (SGLT2) kunyango lwe-2 yeswekile.I-Dapagliflozin lichiza elitsha le-antidiabetic eliphuhliswe ngokudibeneyo yi-Bristol-Myers Squibb kunye ne-AstraZeneca, evunywe yi-Arhente ye-European Medicines Agency (EMA) ngoNovemba 12, 2012. NgoJanuwari 8, 2014, i-US Food and Drug Administration (FDA) iyivumile. ukuba isetyenziswe kunyango lwesifo sikashukela sohlobo lwe-II.