I-5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Ukubonelela ngeVonoprazan Fumarate kunye neNxulumano ePhakathi
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
I-Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
I-Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Igama leMchiza | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| Izithethantonye | I-Vonoprazan Fumarate (TAK-438) ePhakathi 3 |
| Inombolo yeCAS | 881674-56-2 |
| Inombolo yeCAT | RF-PI330 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C11H8FNO |
| Ubunzima beMolekyuli | 189.19 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMthubi ukuya kuBrown |
| Indawo yokunyibilika | 122.0 ~ 131.0℃ |
| Isazisi: RT(HPLC) | Yabelana noMgangatho weReferensi |
| Ilahleko Ekomisweni | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.50% |
| Izinto ezinxulumeneyo | |
| Ubunyulu | ≥99.0% |
| Nakuphi na Ukungacoceki Okukodwa | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤1.0% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kweVonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-5-(2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde (i-CAS 881674-56-2) isebenza njenge-reagent ekulungiseleleni i-synthetic ye-novel pyrrole derivatives njenge-potassium-competitive acid blocker (P-CAB).I-5-(2-Fluorophenyl) pyrrole-3-Carboxaldehyde iphakathi kweVonoprazan Fumarate (CAS 1260141-27-2).I-Vonoprazan fumarate (i-Takecab®), efunyenwe kwaye yaphuhliswa ngu-Takeda no-Otsuka, yavunywa yi-PMDA yaseJapan ngoDisemba 2014, kwaye ibonakaliswe kunyango lwesilonda sesisu, isilonda se-duodenal kunye ne-reflux esophagitis.I-Vonoprazan fumarate inendlela inoveli yesenzo ebizwa ngokuba yi-potassium-competitive acid blockers, ekhuphisana ngokunqanda ukubophelela kwe-ion ye-potassium kwi-H +, i-K + -ATPase (eyaziwa ngokuba yimpompo yeproton) kwinqanaba lokugqibela lokukhutshwa kwe-asidi yesisu kwiiseli ze-parietal zesisu.I-Vonoprazan ayivimbeli umsebenzi we-Na +, i-K + -ATPase nakwizigxina ze-500 ngamaxesha aphakamileyo ngaphezu kwexabiso labo le-IC50 ngokumelene ne-gastric H +, K + -ATPase umsebenzi.Ngaphezu koko, iyeza alichatshazelwa yi-gastric secretory state, ngokungafaniyo neePPI.
