5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4 Dapagliflozin Intermediate Factory
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
I-Dapagliflozin (CAS: 461432-26-8) IziPhakathi eziNxulumeneyo:
I-5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4
I-5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane CAS 461432-23-5
2,3,4,6-Tetrakis-O-Trimethylsilyl-D-Gluconolactone CAS 32384-65-9
Igama leMchiza | I-5-Bromo-2-Chlorobenzoic Acid |
Izithethantonye | I-2-Chloro-5-Bromobenzoic Acid |
Inombolo yeCAS | 21739-92-4 |
Inombolo yeCAT | RF-PI439 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C7H4BrClO2 |
Ubunzima beMolekyuli | 235.46 |
Indawo yokunyibilika | 154.0 ukuya 156.0℃ (lit.) |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | I-Off-White ukuya kwiPowder eKhanyayo etyheli |
Isivavanyi | ≥99.0% |
Amanzi (KF) | ≤0.50% |
Intsalela kwi-Ignition | ≤0.30% |
I-2-Chlorobenzoic Acid | ≤0.30% |
I-2-Chloro-3-Bromobenzoic Acid | ≤0.30% |
Ukungcola ngokupheleleyo | ≤1.0% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Intermediate ye-Dapagliflozin (CAS: 461432-26-8), uhlobo lwe-II yeswekile |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-5-Bromo-2-Chlorobenzoic Acid (i-CAS: 21739-92-4) isetyenziswe njengento yokuqala kwi-synthesis ye-Dapagliflozin (i-CAS: 461432-26-8), i-sodium-glucose cotransporter-2 inhibitor ekhethiweyo enciphisa izintso. i-glucose reabsorption kwaye isetyenziselwa ukunyanga izigulane ezine-type II yeswekile.I-Dapagliflozin inamandla kwaye ikhetha i-SGLT-2 (SLC5A2) inhibitor ene-EC50 ye-1.1 nM.Inokungena kakuhle kwiiseli zeCaco-2 kunye ne-substrate ye-P-glycoprotein (P-gp).I-Dapagliflozin yamkelwa ngo-2012 yi-FDA.