5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4 Dapagliflozin Intermediate Factory
Ubonelelo lwabavelisi, ubunyulu obuphezulu, iMveliso yoRhwebo
I-Dapagliflozin (CAS: 461432-26-8) IziPhakathi eziNxulumeneyo:
I-5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4
I-5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane CAS 461432-23-5
2,3,4,6-Tetrakis-O-Trimethylsilyl-D-Gluconolactone CAS 32384-65-9
| Igama leMchiza | I-5-Bromo-2-Chlorobenzoic Acid |
| Izithethantonye | I-2-Chloro-5-Bromobenzoic Acid |
| Inombolo yeCAS | 21739-92-4 |
| Inombolo yeCAT | RF-PI439 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C7H4BrClO2 |
| Ubunzima beMolekyuli | 235.46 |
| Indawo yokunyibilika | 154.0 ukuya 156.0℃ (lit.) |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | I-Off-White ukuya kwiPowder eKhanyayo etyheli |
| Isivavanyi | ≥99.0% |
| Amanzi (KF) | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.30% |
| I-2-Chlorobenzoic Acid | ≤0.30% |
| I-2-Chloro-3-Bromobenzoic Acid | ≤0.30% |
| Ukungcola ngokupheleleyo | ≤1.0% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Intermediate ye-Dapagliflozin (CAS: 461432-26-8), uhlobo lwe-II yeswekile |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-5-Bromo-2-Chlorobenzoic Acid (i-CAS: 21739-92-4) isetyenziswe njengento yokuqala kwi-synthesis ye-Dapagliflozin (i-CAS: 461432-26-8), i-sodium-glucose cotransporter-2 inhibitor ekhethiweyo enciphisa izintso. i-glucose reabsorption kwaye isetyenziselwa ukunyanga izigulane ezine-type II yeswekile.I-Dapagliflozin inamandla kwaye ikhetha i-SGLT-2 (SLC5A2) inhibitor ene-EC50 ye-1.1 nM.Inokungena kakuhle kwiiseli zeCaco-2 kunye ne-substrate ye-P-glycoprotein (P-gp).I-Dapagliflozin yamkelwa ngo-2012 yi-FDA.
