I-5-Bromo-2-Chloropyrimidine CAS 32779-36-5 Ubunyulu ≥99.5% (HPLC) I-Macitentan Intermediate Factory
Ubonelelo ngezoRhwebo loMvelisi Macitentan aBaphakathi abaNxulumeneyo
5-(4-Bromophenyl)-4,6-Dichloropyrimidine CAS 146533-41-7
5-Bromo-2-Chloropyrimidine CAS 32779-36-5
Igama leMchiza | I-5-Bromo-2-Chloropyrimidine |
Izithethantonye | 2-Chloro-5-Bromopyrimidine;Macitetan Intermediate 5 |
Inombolo yeCAS | 32779-36-5 |
Inombolo yeCAT | RF-PI854 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C4H2BrClN2 |
Ubunzima beMolekyuli | 193.43 |
Indawo yokunyibilika | 73.0~79.0℃ (izibane) |
Indawo yokubilisa | 95℃/15 mmHg |
Ukunyibilika | Inyibilika kwiMethanol;Ayinyibilikiyo emanzini |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kwi-Off-White Powder |
Ukuchongwa | IR/HPLC |
Ubunyulu / Indlela yokuHlalutya | ≥99.5% (HPLC) |
Ukufuma (KF) | ≤0.50% |
Intsalela kwi-Ignition | ≤0.20% |
Ukungacoceki Okukodwa | ≤0.30% |
Ukungcola ngokupheleleyo | ≤0.50% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | abaPhakathi bamayeza;Macitetan Intermediate |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-5-Bromo-2-Chloropyrimidine (i-CAS: 32779-36-5) isetyenziswe njenge-pharmaceutical intermediate, kwi-synthesis ye-Active Pharmaceutical Ingredients (APIs).Kwakhona kuqeshwe kwi-cross-coupling reactions ye-indium organometallics kunye ne-2,5-Dihalopyrimidines.I-5-Bromo-2-Chloropyrimidine iphakathi kweMacitentan (CAS: 441798-33-0).UMacitentan ufumene imvume ye-US FDA ngo-Oktobha 2013 yonyango lwe-pulmonary arterial hypertension (PAH) (iqela le-WHO I) ukulibazisa ukuqhubela phambili kwesifo.