I-5-Fluorocytosine (5-FC) CAS 2022-85-7 Ubunyulu ≥99.5% (HPLC) I-Capecitabine Emtricitabine Intermediate Factory

Inkcazelo emfutshane:

Igama leKhemikhali: 5-Fluorocytosine;5-FC

CAS: 2022-85-7

Imbonakalo: Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe

Ubunyulu: ≥99.5% (HPLC)

I-Intermediate of Capecitabine (CAS: 154361-50-9) kunye ne-Emtricitabine (CAS: 143491-57-0)

Umgangatho ophezulu, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

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Inkcazo:

Unikezelo lwezoRhwebo abaPhakathi abaNxulumeneyo neCapecitabine:
I-5-Fluorocytosine CAS: 2022-85-7
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine CAS: 161599-46-8
I-1,2,3-Tri-O-acetyl-5-deoxy-β-D-ribofuranose CAS: 62211-93-2
Capecitabine CAS: 154361-50-9

Iipropati zeMichiza:

Igama	5-Fluorocytosine
Izithethantonye	5-FC;iFlucytosine;4-Amino-5-fluoro-2-hydroxypyrimidine
Inombolo yeCAS	2022-85-7
Inombolo yeCAT	RF-PI175
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C4H4FN3O
Ubunzima beMolekyuli	129.09
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe
Ukuchongwa kwe-IR	I-spectrum yokufunxa ye-infrared yesampuli kufuneka ihambelane ne-standard spectrum
Ubunyulu / Indlela yokuHlalutya	≥99.5% (HPLC)
Cytosine	≤0.10%
Nakuphi na Okunye Ukungacoceki komntu	≤0.10%
Ukunyibilika	Inyibilika kancinane emanzini;Inyibilika kancinane kutywala;Ngokucacileyo kwiChloroform kunye ne-Ether
Ilahleko ekomisweni	≤1.5% w/w (ku-105℃ 4 h)
Intsalela kwi-Ignition	≤0.10% w/w
Iintsimbi ezinzima (Pb)	≤20ppm
I-Fluonc	≤500ppm
5-Fluorouracil	≤0.10%
Isivavanyi	98.5% ~ 101.0% (ibalwe kwisiseko somisiwe)
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Capecitabine & Emtricitabine Intermediate;AbaPhakathi bamayeza
Umveliso oPhezulu	Cytosine CAS: 71-30-7

I-5-Fluorocytosine (5-FC) CAS: 2022-85-7 Indlela yokuHlalutya
INkangeleko-Mhlophe okanye Phantse uMhlophe Umgubo weCrystalline
Ilahleko ekomiseni-yomise kwi-105 kwiiyure ze-4: ayilahleki ngaphezu kwe-1.50% yobunzima bayo.
Intsalela kwi-Ignition-hayi ngaphezulu kwe-0.1%.
Isinyithi esinzima-kungekho ngaphezu kwe-0.002%.
I-Fluoride-Xuba i-70 mL yesisombululo esandula ukulungiswa se-saturated potassium chloride kunye ne-30 mL ye-isopropyl alcohol, gcwalisa i-electrode nge-supernatant ecacileyo, kwaye uvumele i-electrode ukuba ihlale kumxube ongekho ngaphantsi kweeyure ezi-2 ngaphambi kokusetyenziswa, okanye ngokufanelekileyo ngobusuku.
Xa uthatha imilinganiselo, dlulisela isisombululo kwi-beaker ye-150-mL, kwaye ucwilise i-electrodes.Faka ibha yokuvuselela egqunywe ngepolytef kwibeaker, beka ibhekile kwisivusi-magnethi esinomphezulu ogqunyiweyo, kwaye uvumele ukushukuma de kube ukulingana kufikeleleke (malunga nomzuzu omnye ukuya kwemi-2).Hlanza kwaye uyomise i-electrode phakathi kwemilinganiselo, uqaphele ukuba ungakhuhli ikristale kwi-ion electrode ethile.
Ukulinganisa okunokwenzeka kulungiselelo loMgangatho ngamnye, kwaye wenze isicwangciso soxinaniso lwefluoride, kwi-mg nge-100 mL, ngokuthelekisa nokubanakho, kwi-mV, kwiphepha le-semilogarithmic.Ukulinganisa amandla olungiselelo loVavanyo, kwaye umisele kwigophe eliqhelekileyo lokugxilwa kwefluoride, nge-mg nge-100 mL.Bala ipesenti yefluoride kwinxalenye yeFlucytosine ethathwe ngefomula:
C / 10
apho i-C yi-concentration ye-fluoride, kwi-mg nge-100 mL, ukusuka kwi-curve eqhelekileyo: akukho ngaphezu kwe-0.05% ye-fluoride efunyenweyo.
I-Fluorouracil-Dissolve 250 mg kwi-10 mL yomxube we-glacial acetic acid kunye namanzi (4: 1).Faka i-20 µL yesi sisombululo kwipleyiti yechromatographic ebhityileyo eqatywe ngomxube we-0.5-mm womxube wejeli ye-chromatographic.Kwipleyiti enye faka i-20 µL, kwi-10-µL yonyuso, ye-0.025 mg ngesisombululo se-mL se-USP Fluorouracil RS kumxube we-acetic acid kunye namanzi (4:1).Phuhlisa i-chromatogram kumxube we-chloroform kunye ne-glacial acetic acid (13: 7) de i-solvent front ihambe ingekho ngaphantsi kwe-14 cm ukusuka kwimvelaphi.Susa ipleyiti kwigumbi eliphuhlayo, kwaye uvumele i-solvent ibe ngumphunga.Fumana amabala epleyiti ngokujonga ngaphantsi kobude obufutshane bemitha ye-UV: naliphi na ibala elivela kwisisombululo esiphantsi kovavanyo alikho likhulu ngobungakanani kunye nobukhulu kunendawo ekwiRF echaphazelekayo eveliswe sisisombululo esiPhakathi, esihambelana ne-0.1% fluorouracil.
I-Assay-Place malunga ne-400 mg ye-Flucytosine, ilinganiswe ngokuchanekileyo, kwi-beaker ye-250-mL, yongeza i-150 mL yomxube we-2 ye-glacial acetic acid kunye ne-1 umthamo we-acetic anhydride, kwaye uchithe, ukufudumala ngokukhawuleza ukuba kuyimfuneko.Titrate potentiometrically kunye ne-0.1 N perchloric acid VS, usebenzisa i-calomel-glass electrode system.Yenza isigqibo esingenanto, kwaye wenze naluphi na ulungiso oluyimfuneko.I-mL nganye ye-0.1 N perchloric acid ilingana ne-12.91 mg ye-C4H4FN3O.I-Flucytosine iqulethe ngaphantsi kweepesenti ze-98.5 kwaye ingabi ngaphezu kwe-101.0 ipesenti ye-C4H4FN3O, ibalwa kwisiseko esomileyo.

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

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Isicelo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi okhokelayo kunye nomthengisi we-5-Fluorocytosine CAS: 2022-85-7 (i-Fluorocytosine; i-5-FC) enomgangatho ophezulu, esetyenziswa ngokubanzi kwi-organic synthesis, ukuhlanganiswa kwe-pharmaceutical intermediates kunye ne-Active Pharmaceutical Ingredient. (API) i-synthesis.I-5-Fluorocytosine (i-CAS: 2022-85-7) yindawo ephakathi kwe-Capecitabine (CAS: 154361-50-9) kunye ne-Emtricitabine (CAS: 143491-57-0).

I-5-Fluorocytosine yi-analog ye-cytosine ene-fluorinated.I-5-FC ivunyiwe yi-US Food and Drug Administration (FDA) njenge-antifungal agent esetyenziselwa unyango lwe-Candida kunye ne-Cryptococcus.Kutshanje ngophuhliso lonyango lwemfuza, i-5-FC iye yaziswa njengemveliso edityanisiweyo ne-cytosine deaminase yokuzibulala.