5-Methylisoxazole-4-Carboxylic Acid CAS 42831-50-5 Leflunomide Intermediate Purity >99.0% (HPLC)

Inkcazelo emfutshane:

Igama leKhemikhali: 5-Methylisoxazole-4-Carboxylic Acid

Izithethantonye: 5-Methyl-4-Isoxazolecarboxylic Acid

CAS: 42831-50-5

Ubunyulu: >99.0% (HPLC)

Umgubo weCrystalline oMhlophe ukuya kumthubi, ongenavumba

Umbindi weLeflunomide (CAS: 75706-12-6)

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) enomgangatho ophezulu.I-Ruifu inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, amancinci kunye nezixa ezininzi ezikhoyo.Thenga i-5-Methylisoxazole-4-Carboxylic Acid,Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	5-Methylisoxazole-4-Carboxylic Acid
Izithethantonye	I-5-Methyl-4-Isoxazolecarboxylic Acid
Ukungcola	ILeflunomide EP Ukungcola D/ Leflunomide BP Ukungacoceki D
Ubume beStokhwe	Kwisitokhwe, isikali soRhwebo
Inombolo yeCAS	42831-50-5
Ifomula yeemolekyuli	C5H5NO3
Ubunzima beMolekyuli	127.10 g/mol
Indawo yokunyibilika	145.0 ukuya 149.0℃(lit.)
Ukuxinana	1.348±0.06 g/cm3
Ugcino Temp.	Indawo epholileyo neyomileyo (2~8℃)
I-COA kunye ne-MSDS	Iyafumaneka
Uphawu	Ruifu Chemical

Iinkcukacha:

Izinto	ImiGangatho yokuHlola	Iziphumo
Imbonakalo	Umgubo weCrystalline oMhlophe ukuya kumthubi, ongenavumba	Iyahambelana
Indawo yokunyibilika	145.0 ukuya 149.0℃	147.8 ~ 148.5℃
Ilahleko ekomisweni	≤0.50%	0.13%
Intsalela kwi-Ignition	≤0.10%	0.04%
Iintsimbi ezinzima (Pb)	≤0.002%	<0.002%
3-Methyl Isomeric Compound	≤0.20%	<0.20%
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)	99.74%
I-Infrared Spectrum	Iyahambelana neSakhiwo	Iyahambelana
I-1 H NMR Spectrum	Iyahambelana neSakhiwo	Iyahambelana
Ukuqukumbela	Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo
Usebenzisa	I-Pharmaceutical Intermediate ye-Leflunomide (CAS: 75706-12-6)

Ukupakishwa/uGcino/Ukuhambisa ngenqanawe:

Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwisitya esivaliweyo.Gcina kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engenamoya kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
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Izinto eziluncedo:

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Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

FAQ:

Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.

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Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.

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MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.

Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.

Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.

Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.

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42831-50-5 - Umngcipheko kunye noKhuseleko:

Iikhowudi zoMngcipheko
R36/37/38 - Ukucaphukisa emehlweni, inkqubo yokuphefumla kunye nolusu.
I-R37/38 - Iyacaphukisa inkqubo yokuphefumla kunye nolusu.
R36 - Iyandicaphukisa emehlweni
I-R10 -Inokutsha
Inkcazelo yoKhuseleko
S22 - Musa ukuphefumla uthuli.
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36/37/39 - Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo / ubuso.
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
S16 - Gcina kude kwimithombo yomlilo.
WGK eJamani 3
Ikhowudi yeHS 2917399090
I-Hazard Class IRRITANT

Isicelo:

I-5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) yindawo ephakathi kwi-synthesis ye-Leflunomide (CAS: 75706-12-6).I-Leflunomide luhlobo lweziyobisi ze-isoxazole ze-immunosuppressive kunye nomsebenzi ochasayo, i-pharmacology yanamhlanje ichaza le mveliso njenge-antipyretic, i-analgesic kunye neyeza ezichasayo.Le mveliso inokuguqulwa ngokukhawuleza kwi-metabolites esebenzayo kwaye idlale indima yesibindi kunye ne-intestinal cytoplasm kunye ne-microsomes, yayo;eyona ndlela iphambili ngexesha le-DNA synthesis, inhibiting i-enzyme engundoqo-DHODH (DHODH) umsebenzi, ukwenzela ukuba i-nucleotides ngaphakathi kwe-lymphocyte ye-B iphele, iphelisa i-biosynthesis ye-DNA kunye ne-RNA, iiseli azikwazi ukungena kwisigaba, kwaye ekugqibeleni azikwazi. ukwanda, okubangelwa yi-anti-rheumatic effects, ifanelekile kunyango lwabantu abadala abane-arthritis esebenzayo ye-rheumatoid, i-ankylosing spondylitis, inokucothisa ukutshatyalaliswa kwamathambo, ukunciphisa iimpawu kunye neempawu.Ukongeza, i-leflunomide inokuthintela umsebenzi we-tyrosine kinase, ngaloo ndlela inqanda ukwanda kweeseli ze-T, iiseli ze-B kunye neeseli ezingezizo amajoni omzimba, kodwa inokuthi, nge-biosynthesis inhibition ye-cyclooxygenase-2 (COX2), inhibit prostaglandin synthesis kwaye isebenzise i-anti- iziphumo ezivuthayo kunye nokuthintela iiseli zemast kunye ne-basophils histamine release.Xa le mveliso isetyenziselwa izigulana zokufakelwa kwamalungu, ukulungiswa kwedosi kunzima, kusetyenziselwa ukunyanga i-rheumatoid arthritis kunye nezinye izifo ezizimele.