I-6-Amino-5-Bromoquinoxaline CAS 50358-63-9 Ubunyulu > 99.0% (HPLC) Brimonidine Tartrate Intermediate

Inkcazelo emfutshane:

Igama leKhemikhali: 6-Amino-5-Bromoquinoxaline

Izithethantonye: 5-Bromoquinoxalin-6-Amine

CAS: 50358-63-9

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Brown ukuya kwi-Light-Yellow Powder

Phakathi kweBrimonidine Tartrate (CAS: 70359-46-5)

Qhagamshelana: UGqr. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 6-Amino-5-Bromoquinoxaline (CAS: 50358-63-9) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	I-6-Amino-5-Bromoquinoxaline
Izithethantonye	5-Bromoquinoxalin-6-Amine;5-Bromo-6-Quinoxalinamine;5-Bromo-6-Aminoquinoxaline
Ukungcola	Brimonidine EP Ukungcola B
Inombolo yeCAS	50358-63-9
Inombolo yeCAT	RF2515
Ubume beStokhwe	KwiSitokhwe, Umthamo weMveliso iiToni ezingama-35 ngenyanga
Ifomula yeemolekyuli	I-C8H6BrN3
Ubunzima beMolekyuli	224.06
Indawo yokunyibilika	153.0 ukuba 157.0℃
Ukuxinana	1.744±0.06 g/cm3
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	I-Brown ukuya kwi-Light-Yellow Powder
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Indawo yokunyibilika	153.0 ~ 157.0℃
Ilahleko ekomisweni	<1.00%
Max.Ukungacoceki komntu	<0.50%
Ukungcola ngokupheleleyo	<1.00%
I-Infrared Spectrum	Iyahambelana neSakhiwo
Proton NMR Spectrum	Iyahambelana neSakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kweBrimonidine Tartrate (CAS: 70359-46-5)

Indawo yokunyibilika
Sebenzisa indlela yokuvavanya ngokubanzi kwaye unyuse ubushushu be-1.5℃/minute.Kufuneka inyibilike phakathi kwe-153.0 ~ 157.0℃
Ilahleko ekomisweni
Akukho ngaphezu kwe-1.0% Emiselwe kwi-1.0g ngokomisa kwi-oven kwi-105 ℃ ukuya kubunzima obuqhubekayo
Iikhompawundi ezinxulumeneyo (HPLC)
Inkqubo yeChromatographic:
Uluhlu: ODS, C18,
Umtshina wavelengh: 264nm
Izinga lokuhamba: 1.0 ml ngomzuzu
Isigaba esiphathwayo:
Lungiselela umxube ohluziweyo kunye ne-degassed ye-buffer ( chitha i-2.6g ye-Sodium 1-heptanesulfonate kwi-690ml yamanzi) -methanol-glacial acetic acid-triethylamine (690: 310: 7.5: 2.5) .
Ukulungiswa kwesampula yesisombululo:
Dissolve isampuli esikali ngokuchanekileyo 25.0mg in 25ml mobile isigaba.
Inkqubo:
Faka umthamo we-10 l yesisombululo sesampulu kwaye urekhode iichromatograms ukuya kuma-4 amaxesha okugcinwa kwexesha eliphambili.Bala iincopho zokungcola nciphisa incopho engenanto.Iyonke
ukungcola akukho ngaphezu kwe-1.00%, nakuphi na ukungcola komntu kungekhona ngaphezu kwe-0.50%.

Indlela ye-Synthesis ye-6-Amino-5-Bromoquinoxaline (CAS: 50358-63-9)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

Umthamo owaneleyo: Izixhobo ezaneleyo kunye namagcisa

Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

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Isicelo:

I-6-Amino-5-Bromoquinoxaline (i-CAS: 50358-63-9) yinto ebalulekileyo ephakathi kwe-quinoxaline derivatives.I-6-Amino-5-Bromoquinoxaline isetyenziswe njenge-pharmaceutical intermediate, i-intermediate ye-Brimonidine Tartrate (CAS: 70359-46-5).I-Brimonidine i-blocker ekhethiweyo kakhulu ye-α2-receptor, ephuhliswe ngempumelelo yi-US Company Allergan, eyona iyeza lamehlo.Inokunciphisa uxinzelelo lwe-intraocular (IOP).I-Brimonidine Tartrate isisombululo se-ophthalmic saling kwimarike luhlobo lwe-brimonidine tartrate, eliyeza elilungileyo le-IOP-lehlisa i-glaucoma evulekileyo engapheliyo kunye nonyango loxinzelelo lwamehlo kwizigulana, kodwa nakumanqanaba e-argon laser IOP.Isisombululo se-Brimonidine Tartrate ophthalmic sineendlela ezimbini zesenzo ngokunciphisa imveliso ye-aqueous humor kunye nokwandisa i-pigment layer ye-liquid scleral outflow therapy ngeenjongo zonyango.Emva kokulahla iliso, umphumo ukhawuleza, kwaye unokufikelela kwincopho xa usebenzisa ukuya kwi-2h, kwaye ixesha elisebenzayo linokugcina i-12h.Igazi liyakwazi ukubona kuphela iithontsi zamachiza.Le mveliso ine-metabolism yokuqala yokudlula kwisibindi, kwaye i-metabolites ekhutshwe kumchamo ngezintso.Ukufakwa kwenkqubo kunye nokusabalalisa akuchaphazeli, kwaye abantu abadala abafuni ukulungiswa kwedosi.I-Brimonidine Tartrate isisombululo se-ophthalmic xa kuthelekiswa nezinye i-α-blockers, i-fat-soluble incinci, ngelixa ingekho lula ukudlula umqobo wegazi-ingqondo kwaye ayivelisi i-sedation, hypotension kunye nezinye i-clonidine central reactions ezimbi.