I-6-Iodoindazole CAS 261953-36-0 Ubunyulu > 98.5% (HPLC) Factory

Inkcazelo emfutshane:

Igama leKhemikhali: 6-Iodoindazole

Izithethantonye: 6-Iodo(1H)indazole;6-Iodo-1H-Indazole

CAS: 261953-36-0

Ubunyulu: >98.5% (HPLC)

Imbonakalo: Yellow Solid

UMphakathi oPhambili we-Axitinib (CAS: 319460-85-0)

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Inkcazo:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 6-Iodoindazole (CAS: 261953-36-0) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	6-Iodoindazole
Izithethantonye	6-Iodo(1H)indazole;6-Iodo-1H-Indazole
Inombolo yeCAS	261953-36-0
Inombolo yeCAT	RF2672
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C7H5IN2
Ubunzima beMolekyuli	244.04
Indawo yokunyibilika	207.0 ukuba 211.0℃
Indawo yokubilisa	358.2±15.0℃
Ukuxinana	2.082±0.06 g/cm3
Inovakalelo	UkuKhanya okungevayo, ukungeva komoya
Ukunyibilika	I-DMSO (Kancinci), iMethanol (Kancinci)
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mthubi Okuqinileyo
I-1H NMR Spectrum	Ukungqinelana Nolwakhiwo
IMisa	Iyahambelana
Ubunyulu / Indlela yokuHlalutya	>98.5% (HPLC)
Indawo yokunyibilika	207.0 ukuba 211.0℃
Ilahleko ekomisweni	<0.50%
Ukungcola ngokupheleleyo	<1.50%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	UMphakathi oPhambili we-Synthesis ye-Axitinib (CAS: 319460-85-0)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

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Inkonzo yobuNgcali: Inkonzo enye yokuyeka ukuthenga

Ipakethe ye-OEM: Iphakheji yesiko kunye neleyibhile ekhoyo

Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

Inkxaso yobuGcisa: Isisombululo seTekhnoloji siyafumaneka

Inkonzo yesiNtu yoHlanganiso: Isuka kwiigram ukuya kwiikhilos

Umgangatho ophezulu: Kusekwe inkqubo epheleleyo yokuqinisekisa umgangatho

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Isicelo:

I-6-Iodoindazole (i-CAS: i-261953-36-0) isetyenziswe njengama-pharmaceutical intermediates.I-6-Iodoindazole ingundoqo ephakathi kwe-synthesis ye-Axitinib (i-CAS: 319460-85-0).NgoJanuwari 27, 2012, i-FDA ivume i-axitinib yonyango lomhlaza wezintso eziphambili (i-renal cell carcinoma) ezinye iziyobisi ezingaphenduliyo.I-Inlyta yenziwa kwaye ithengiswe nguPfizer, kwaye yipilisi yomlomo ethathwa kabini ngemini.I-Renal cell carcinoma luhlobo lwethumba olusuka kwiiseli ze-tubular endothelial.I-Axitinib inokuthintela iprotheni ethile ebizwa ngokuba yi-kinases edlala indima ekukhuleni kwethumba kunye ne-metastasis.I-Axitinib yi-molecule encinci ye-tyrosine kinase inhibitor, esebenzayo ngokuchasene neethagethi ezininzi, kuquka i-VEGF receptors 1, 2 kunye ne-3. I-Axitinib yi-VEGFR inhibitor (IC50s = 1.2, 0.25, kunye ne-0.29 nM ye-VEGFR1, -2, kunye -3, ngokulandelanayo) .