I-6-Nitroindazole CAS 7597-18-4 Ubunyulu > 98.0% (GC) Factory

Inkcazelo emfutshane:

Igama leKhemikhali: 6-Nitroindazole

Izithethantonye: 6-Nitro-1H-Indazole

CAS: 7597-18-4

Ubunyulu: >98.0% (GC)

Imbonakalo: Mthubi oKhanyayo ukuya kwiPowder eBrown eKhanyayo

Umgangatho ophezulu, iMveliso yoRhwebo

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Inkcazo:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 6-Nitroindazole (CAS: 7597-18-4) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Iipropati zeMichiza:

Igama leMchiza	6-Nitroindazole
Izithethantonye	6-Nitro-1H-Indazole;6-Nitro-1(2)H-Indazole;6-Nitro-Indazole
Inombolo yeCAS	7597-18-4
Inombolo yeCAT	RF2675
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C7H5N3O2
Ubunzima beMolekyuli	180.0 ukuba 184.0163.14
Ukuxinana	1.525
Ukunyibilika kwiMethanol eshushu	I-Turbidity eFaint kakhulu
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umthubi oKhanyayo ukuya kwiPowder emdaka
Ubunyulu / Indlela yokuHlalutya	>98.0% (GC)
Indawo yokunyibilika	180.0 ukuya 184.0℃
Ilahleko ekomisweni	<1.00%
Ukungcola ngokupheleleyo	<2.00%
I-Infrared Spectrum	Iyahambelana neSakhiwo
Proton NMR Spectrum	Iyahambelana neSakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	AbaPhakathi bamayeza

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

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Ukuhanjiswa ngokukhawuleza: Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe

Ubonelelo oluzinzileyo: Gcina isitokhwe esifanelekileyo

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Isicelo:

I-6-Nitroindazole (i-CAS: 7597-18-4) isetyenziswe njenge-pharmaceutical intermediate, i-Axitinib / AG013736 ephakathi.I-Axitinib (AG-013736) yi-inhibitor ejoliswe kuyo emininzi ye-VEGFR1, VEGFR2, VEGFR3, PDGFRβ kunye ne-c-Kit ene-IC50 ye-0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM kunye ne-1.7 nM, ngokulandelanayo.I-Axitinib yi-tyrosine kinase inhibitor.I-Axitinib isetyenziselwa unyango lomhlaza.NgoJanuwari 2012, i-US FDA ivume i-axitinib (ekwabizwa ngokuba yi-AG-013736) yonyango lwe-renal cell carcinoma (RCC) yezigulane ezingakhange ziphendule unyango lwangaphambili.I-Axitinib yi-pan ye-VEGF inhibitor kwaye isebenza ngokubophelela kwi-intracellular tyrosine kinase catalytic domain ye-VEGF ekhokelela kwibhlokhi yokubonisa umqondiso ngale ndlela ye-angiogenic.