I-6-O-Methylguanine CAS 20535-83-5 iNelzarabine Intermediate Factory
Nikeza ngokucoceka okuphezulu, iMveliso yoRhwebo
Igama leKhemikhali: 6-O-Methylguanine
CAS: 20535-83-5
| Igama leMchiza | 6-O-Methylguanine |
| Izithethantonye | I-2-Amino-6-Methoxypurine |
| Inombolo yeCAS | 20535-83-5 |
| Inombolo yeCAT | RF-PI509 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | C6H7N5O |
| Ubunzima beMolekyuli | 165.16 |
| Indawo yokunyibilika | >300℃ (ilayiti.) |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo weCrystalline oMhlophe |
| Indlela yoVavanyo / yoHlahlelo | ≥98.5% (HPLC) |
| Ilahleko ekomisweni | ≤0.50% |
| Intsalela kwi-Ignition | ≤0.50% |
| Ukungcola ngokupheleleyo | ≤1.5% |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | Phakathi kweNelzarabine (CAS: 121032-29-9), T-ALL & T-LBL |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
I-6-O-Methylguanine (i-CAS: 20535-83-5) ingasetyenziselwa njengendawo ephakathi kwi-synthesis ye-Nelzarabine (CAS: 121032-29-9).I-Nelarabine yiprodrug ye-deoxyguanosine analogue-9-beta-D-arabinofuranosyl guanine (ara-G).I-Nelarabine demethylates kwindima ye-adenosine deaminase (ADA) kwaye ijika ibe yi-ara-G.INelarabine yaphuhliswa ngempumelelo nguGlaxoSmithKline.Ngo-Oktobha 28, 2005 phantsi kwemvume ye-US Food and Drug Administration, yaba lichiza elitsha lokunyanga i-T-cell acute lymphoblastic leukemia (T-ALL) kunye ne-T-Cells lymphoblasticlymphoma (T-LBL) ezixhathisayo ubuncinane. iintlobo ezimbini zeerejimeni zechemotherapy okanye zibuyele emva konyango lokuqala.Eli chiza litsha ladweliswa ngokusemthethweni eUnited States ngo-2006.
