7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3 Tolvaptan Intermediate
Ubonelelo loMvelisi, uMgangatho oPhezulu, iMveliso yoRhwebo
I-Tolvaptan kunye nabaPhakathi abaNxulumeneyo:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
I-4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
I-2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
Igama leMchiza | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye |
Izithethantonye | I-7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-enye;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-enye |
Inombolo yeCAS | 160129-45-3 |
Inombolo yeCAT | RF-PI395 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C10H10ClNO |
Ubunzima beMolekyuli | 195.65 |
Indawo yokunyibilika | 103.0 ukuba 107.0℃ |
Ukunyibilika | Inyibilika kwiMethanol |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | UBuhlaza obuKhanyayo ukuya kumgubo oMthubi oKhanyayo |
Iindlela zokuchongwa | NMR, HPLC |
Ubunyulu / Indlela yokuHlalutya | ≥99.0% (HPLC) |
Ilahleko ekomisweni | ≤1.0% |
Intsalela kwi-Ignition | ≤0.50% |
Nakuphi na Ukungacoceki Okukodwa | ≤0.50% |
Ukungcola ngokupheleleyo | ≤1.0% |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Phakathi kweTolvaptan (CAS 150683-30-0), unyango lwe-Hyponatremia |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.
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I-7-Chloro-1,2,3,4-tetrahydrobenzo [b] i-azepin-5-enye (i-CAS 160129-45-3) iphakathi kwi-synthesis ye-Tolvaptan (CAS 150683-30-0).I-Tolvaptan yinto ekhethiweyo, ekhuphisanayo ngomlomo esebenzayo i-nonpeptide arginine vasopressin V2 i-receptor antagonist kunye ne-IC50 ye-1.28µM yokuthintela i-AVP-induced platelet aggregation.I-Tolvaptan isetyenziselwa ukunyanga i-hyponatremia ehambelana nokungaphumeleli kwentliziyo, i-cirrhosis, kunye ne-syndrome ye-antidiuretic hormone engafanelekanga.I-Tolvaptan ikwakwizilingo zeklinikhi ezikhawulezayo zesifo sezintso ze-polycystic.Unyango ngeTolvaptan lubangela ukuthotywa kobunzima bomzimba obukhawulezayo nobuzinzileyo ngaxeshanye kunye nokunyuka kokuphuma komchamo, kuphucula kunye/okanye kulungelelanisa i-serum sodium kwizigulane ze-hyponatremic, kunciphisa iimpawu kunye neempawu zokuxinana kunye nokwandisa ukoma.