I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Ubunyulu >99.0% (HPLC) I-Afatinib Dimaleate iFactory Intermediate Factory Featured Image

I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Ucoceko >99.0% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Inkcazelo emfutshane:

Igama: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

CAS: 53449-14-2

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Mthubi oKhanyayo ukuya kwiPowder eBrown eKhanyayo

Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	I-7-Chloro-6-Nitro-4-Hydroxyquinazoline
Izithethantonye	I-7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4(3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-enye;I-7-Chloro-6-Nitroquinazolin-4 (3H) -enye
Inombolo yeCAS	53449-14-2
Inombolo yeCAT	RF-PI2030
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C8H4ClN3O3
Ubunzima beMolekyuli	225.59
Uvakalelo	Ubushushu Bubuthathaka
Ukunyibilika	Inyibilika kancinane kwiDimethylformamide
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umthubi oKhanyayo ukuya kwiPowder emdaka
Ukuchongwa (HPLC)	Ixesha lokugcinwa kweSampuli kufuneka lihambelane neMigangatho
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Indawo yokunyibilika	300.0 ~ 303.0℃
Isiqulatho samanzi (KF)	<0.50%
Intsalela kwi-Ignition	<0.30%
Ukungcola 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
Ukungacoceki 2	<0.50% (5,7-Dichloro-4[1H]quinazolinone)
Ukungacoceki 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Okunye Ukungcola Okukodwa	<0.20%
Ukungcola ngokupheleleyo	<1.00%
Iintsimbi ezinzima (njenge Pb)	<20ppm
I-Infrared Spectrum	Iyahambelana neSakhiwo
Proton NMR Spectrum	Proton NMR Spectrum
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Umbindi weAfatinib, Afatinib Dimaleate

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-7-Chloro-6-Nitro-4-Hydroxyquinazoline (i-CAS: 53449-14-2) iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib lusapho lwe-ErbB olungajikiyo lwezithinteli ezicinezela usasazo lolwazi kunye nokuthintela iindlela eziphambili ezibandakanyekayo ekukhuleni kweeseli zomhlaza kunye nokwahlukana.Ngenxa yokuba i-ErbB yolwazi lwentsapho i-transduction indlela yokudlulisa ulwazi inokuthi iqhutywe ngama-homodimers amaninzi kunye ne-heterodimers, ukuvinjelwa kwangaxeshanye kwamalungu amaninzi osapho lwe-ErbB (njenge-EGFR, i-HER2, i-ErbB3 kunye ne-ErbB4) inokuphazamisa ngokufanelekileyo ukuhanjiswa kolwazi olusezantsi.I-Afatinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wemiphunga (umhlaza wemiphunga ongeyonxalenye encinci) othe wasasazeka kwamanye amalungu omzimba.Kukwiklasi yeziyobisi ezaziwa ngokuba yi-kinase inhibitors.Isebenza ngokucotha okanye ukumisa ukukhula kweeseli zomhlaza.Ibophelela kwiprotheni ethile (i-epidermal receptor-EGFR) kwezinye izicubu.