I-7-Fluoro-6-Nitroquinazolin-4 (1H)-enye i-CAS 162012-69-3 Ucoceko > 99.0% (HPLC) I-Afatinib Dimaleate iFactory Intermediate Factory Featured Image

I-7-Fluoro-6-Nitroquinazolin-4 (1H)-enye i-CAS 162012-69-3 Ucoceko > 99.0% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Inkcazelo emfutshane:

Igama leKhemikhali: 7-Fluoro-6-Nitroquinazolin-4 (1H) -enye

CAS: 162012-69-3

Ubunyulu: >99.0% (HPLC)

Mthubi ukuya kuBomvu iCrystal etyheli okanye uPowder

Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Umgangatho ophezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-enye CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Iipropati zeMichiza:

Igama leMchiza	7-Fluoro-6-Nitroquinazolin-4 (1H)-enye
Izithethantonye	I-7-Fluoro-6-Nitroquinazolin-4 (3H) -enye;I-7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;I-7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-enye
Inombolo yeCAS	162012-69-3
Inombolo yeCAT	RF-PI2025
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C8H4FN3O3
Ubunzima beMolekyuli	209.13
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mthubi ukuya kuBomvu iCrystal etyheli okanye uPowder
I-1 H NMR Spectrum	Ukungqinelana Nolwakhiwo
Ubunyulu / Indlela yokuHlalutya	>99.0% (HPLC)
Ilahleko ekomisweni	<0.50%
Ukungcola ngokupheleleyo	<1.00%
Proton NMR Spectrum	Iyahambelana neSakhiwo
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Phakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

Izinto eziluncedo:

FAQ:

Isicelo:

I-7-Fluoro-6-Nitroquinazolin-4 (1H)-enye (i-CAS: 162012-69-3) iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib lusapho lwe-ErbB olungajikiyo lwezithinteli ezicinezela usasazo lolwazi kunye nokuthintela iindlela eziphambili ezibandakanyekayo ekukhuleni kweeseli zomhlaza kunye nokwahlukana.Ngenxa yokuba i-ErbB yolwazi lwentsapho i-transduction indlela yokudlulisa ulwazi inokuthi iqhutywe ngama-homodimers amaninzi kunye ne-heterodimers, ukuvinjelwa kwangaxeshanye kwamalungu amaninzi osapho lwe-ErbB (njenge-EGFR, i-HER2, i-ErbB3 kunye ne-ErbB4) inokuphazamisa ngokufanelekileyo ukuhanjiswa kolwazi olusezantsi.I-Afatinib lichiza elivunyiweyo kunyango lwe-non-small cell lung carcinoma(NSCLC), ephuhliswe ngu-Boehringer Ingelheim.Isebenza njenge-angiokinase inhibitor.Njenge-lapatinib kunye ne-neratinib, i-afatinib yi-tyrosine kinase inhibitor (TKI) ephinda ivimbele ngokungenakuguquleka i-epidermal growth factor receptor 2 (Her2) kunye ne-epidermal growth factor receptor (EGFR) kinases.I-Afatinib ayisebenzi kuphela ngokuchasene nokuguqulwa kwe-EGFR ekujoliswe kuyo kwisizukulwana sokuqala se-TKIs likeerlotinib okanye i-gefitinib, kodwa nakwabo bangenaluvelwano kolu nyango luqhelekileyo.Ngenxa yomsebenzi wayo owongezelelweyo ngokuchasene ne-Her2, iphandwa umhlaza wamabele kunye neminye imihlaza eqhutywa yi-EGFR kunye ne-Her2.