I-7-Hydroxy-3,4-Dihydro-2 (1H)-Quinolinone CAS 22246-18-0 Ucoceko >99.0% (HPLC) i-Aripiprazole Intermediate Factory
AbaPhakathi boBonelelo boMvelisi be-Aripiprazole Ngobunyulu obuPhezulu
Aripiprazole API CAS 129722-12-9
1-(2,3-Dichlorophenyl)piperazine Hydrochloride CAS 119532-26-2
I-7-Hydroxy-3,4-Dihydro-2 (1H)-Quinolinone CAS 22246-18-0
7-(4-Bromobutoxy)-3,4-Dihydro-2(1H)-Quinolinone CAS 129722-34-5
Igama leMchiza | I-7-Hydroxy-3,4-Dihydro-2 (1H) -Quinolinone |
Izithethantonye | I-3,4-Dihydro-7-Hydroxy-2 (1H) -Quinolinone;I-7-Hydroxy-3,4-Dihydrocarbostyril;I-7-Hydroxy-2-oxo-1,2,3,4-Tetrahydroquinoline;7-Hydroxycarbostyril;Ukungacoceki kwe-Aripiprazole 5;Aripiprazole EP Ukungcola A |
Inombolo yeCAS | 22246-18-0 |
Inombolo yeCAT | RF-PI1981 |
Ubume beStokhwe | KwiSitokhwe, iMveliso yeMveliso ye60MT/Unyaka |
Ifomula yeemolekyuli | C9H9NO2 |
Ubunzima beMolekyuli | 163.18 |
Ukunyibilika | Inyibilika kwiMethanol |
Ukuxinana | 1.282±0.060 g/cm3 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMthubi oMthulu okanye ophantse wamhlophe |
Ubunyulu / Indlela yokuHlalutya | >99.5% (HPLC, Ipesenti yommandla) |
Indawo yokunyibilika | 229.0 ~ 235.0℃ |
Ilahleko ekomisweni | <0.50% |
Isiqulatho samanzi (KF) | <0.50% |
Ukungacoceki okuphezulu okukodwa | <0.30% |
Ukungcola ngokupheleleyo | <0.50% |
I-Infrared Spectrum | Iyahambelana neSakhiwo |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | Umbindi we-Aripiprazole (CAS: 129722-12-9) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-Methyl 3-Bromobenzoate (i-CAS 618-89-3) ingasetyenziselwa njenge-precursor ye-Aripiprazole (CAS: 129722-12-9).I-Aripiprazole luhlobo olutsha lwezinto eziphuma kwi-quinoline ezine-lipid enyibilikayo, iimpawu zayo ze-pharmacological kukuba ayisiyiyo kuphela i-postsynaptic dopamine D 2 receptor antagonist, kodwa kunye ne-presynaptic dopamine D 2 receptor agonist, inokuvuyisa i-D 1, D 3, D 4 i-receptors;I-Aripiprazole ineempembelelo ezimbini ze-activation partial okanye i-receptor antagonistic kwi-5-HT 1A receptor;inesenzo esichasayo ngokupheleleyo kwi-5-HT 2A receptor.Olu phawu lwahlukile kwisizukulwana sokuqala, kunye ne-atypical antipsychotics eyeyesibini isizukulwana sesibini seziyobisi, kwaye ke ibizwa ngokuba yi-dopamine system stabilizer okanye i-antipsychotic yesizukulwana sesithathu.Kuba ithengiswa kwimarike, i-Aripiprazole isetyenziswa ikakhulu kwi-schizophrenia yeklinikhi, unyango lweengxaki ezichaphazelekayo kunye nezinye iingxaki zengqondo.Ngokutsho kweencwadi, i-aripiprazole ineempembelelo ezibalulekileyo kwi-schizophrenia iimpawu ezintle kunye ezimbi kunye nokuxhalaba, ukudakumba, umsebenzi wokuqonda, ngelixa ukhuseleko oluphezulu.AripiprazoleKwakhona kwaxelwa ukuba ichiza nako ukunyanga ezinye ukuphazamiseka kwengqondo, ezifana ukuphazamiseka kweemvakalelo manic episodes, senile dementia ezinxulumene nokuphazamiseka kwengqondo, ukuphazamiseka ixhala, ukuphazamiseka ukuziphatha abantwana, ukudakumba.