7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2 Purity >99.5% (HPLC) Agomelatine Intermediate Factory
UMvelisi oPhambili kunye noMboneleli we-Agomelatine Intermediates
Agomelatine CAS 138112-76-2
I-7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
Please contact: alvin@ruifuchem.com
| Igama leMchiza | I-7-Methoxy-1-Naphthaleneacetic Acid |
| Izithethantonye | (7-Methoxy-1-Naphthyl)i-acetic Acid;I-2-(7-Methoxynaphthalen-1-yl) i-acetic Acid;I-2-(7-Methoxy-1-Naphthyl) i-acetic Acid |
| Inombolo yeCAS | 6836-22-2 |
| Inombolo yeCAT | RF2688 |
| Ubume beStokhwe | KwiSitokhwe, Umthamo weMveliso iiToni ezingama-20 ngenyanga |
| Ifomula yeemolekyuli | C13H12O3 |
| Ubunzima beMolekyuli | 216.24 |
| Indawo yokunyibilika | 153.0 ukuba 158.0℃ |
| Indawo yokubilisa | 408.8±20.0℃ |
| Ukuxinana | 1.235 |
| Ukunyibilika | Inyibilika kwiMethanol |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo oMthubi oKhanyayo |
| Ubunyulu / Indlela yokuHlalutya | >99.5% (HPLC) |
| Indawo yokunyibilika | 153.0 ~ 158.0℃ |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.20% |
| Ukungacoceki Okukodwa | <0.50% |
| Ukungcola ngokupheleleyo | <0.50% |
| I-1 H NMR Spectrum | Ukungqinelana Nolwakhiwo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Pharmaceutical Intermediate ye-Agomelatine (CAS: 138112-76-2) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-7-Methoxy-1-Naphthaleneacetic Acid (CAS: 6836-22-2) iphakathi kwe-Agomelatine (CAS: 138112-76-2).I-Agomelatine sisithomalalisi sokudakumba esisetyenziselwa ukunyanga ukudakumba.Ingqondo idla ngokwenza kakuhle ekuqinisekiseni ukuba sinemichiza eyaneleyo esiyidingayo ukuze sisebenze kakuhle.Kodwa ukudakumba kunokuchaphazela inani leekhemikhali zengqondo.Ezi khemikhali ziquka i-noradrenaline, i-dopamine kunye ne-serotonin;ukudakumba kunciphisa amanqanaba aba bathumeli bobuchopho.Uxinezeleko lukwachaphazela umchiza obizwa ngokuba yimelatonin.Ukuncipha kwemelatonin kunxulunyaniswa nokuphazamiseka kwindlela esilala ngayo.I-Agomelatine yi-antidepressant yokuqala yokwandisa umsebenzi we-melatonin ngokuthe ngqo.Ikwenza oku ngokusebenza njengemelatonin kwiindawo ekujoliswe kuzo apho imelatonin isebenza khona.(Ezi zaziwa njenge melatonin receptors).Ngokunyusa umsebenzi we-melatonin, i-agomelatine ikwanyusa ngokuthe ngqo umsebenzi we-noradrenaline kunye ne-dopamine.I-Agomelatine ineziphumo ezithile zokulwa nokuxhalaba, ikhulula ukuphuthelwa kubantu abanoxinzelelo.IAgomelatine ilawula umjikelo wokuvuka komzimba.I-Agomelatine yinkqubela phambili kunyango lokudakumba.I-Agomelatine iphuhliswa yinkampani yoxubo-mayeza i-Servier.Ithengiswa ngonyango lwengxaki enkulu yokudakumba kwaye kuye kwabikwa ukuba ayivelisi i-discontinuation syndrome kwaye ayinayo imiphumo yecala lezesondo xa kuthelekiswa ne-SSRIs, i-SNRIs kunye ne-tricyclic endala ye-antidepressants.I-Agomelatine inokuba neziphumo ezilungileyo ekulaleni.
